Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens
To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were n...
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| Format: | Article |
| Language: | English |
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Infectious Diseases Society of America
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40244/ http://psasir.upm.edu.my/id/eprint/40244/1/Clinical%20outcomes%20of%20pneumococcal%20pneumonia%20caused%20by%20antibiotic-resistant%20strains%20in%20Asian%20countries.pdf |
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| author | Song, Jae Hoon Jung, Sook In Ki, Hyun Kyun Shin, Myung Hee Ko, Kwan Soo Son, Jun Seong Chang, Hyun Ha Kim, Shin Woo Lee, Hyuck Kim, Yeon Sook Oh, Won Sup Peck, Kyong Ran Chongthaleong, Anan Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Jamal, Farida Kamarulzaman, Adeeba Carlos, Celia Carpio So, Thomas Man Kit |
| author_facet | Song, Jae Hoon Jung, Sook In Ki, Hyun Kyun Shin, Myung Hee Ko, Kwan Soo Son, Jun Seong Chang, Hyun Ha Kim, Shin Woo Lee, Hyuck Kim, Yeon Sook Oh, Won Sup Peck, Kyong Ran Chongthaleong, Anan Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Jamal, Farida Kamarulzaman, Adeeba Carlos, Celia Carpio So, Thomas Man Kit |
| author_sort | Song, Jae Hoon |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance. |
| first_indexed | 2025-11-15T09:49:19Z |
| format | Article |
| id | upm-40244 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:49:19Z |
| publishDate | 2004 |
| publisher | Infectious Diseases Society of America |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-402442015-09-15T00:02:30Z http://psasir.upm.edu.my/id/eprint/40244/ Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens Song, Jae Hoon Jung, Sook In Ki, Hyun Kyun Shin, Myung Hee Ko, Kwan Soo Son, Jun Seong Chang, Hyun Ha Kim, Shin Woo Lee, Hyuck Kim, Yeon Sook Oh, Won Sup Peck, Kyong Ran Chongthaleong, Anan Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Jamal, Farida Kamarulzaman, Adeeba Carlos, Celia Carpio So, Thomas Man Kit To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance. Infectious Diseases Society of America 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40244/1/Clinical%20outcomes%20of%20pneumococcal%20pneumonia%20caused%20by%20antibiotic-resistant%20strains%20in%20Asian%20countries.pdf Song, Jae Hoon and Jung, Sook In and Ki, Hyun Kyun and Shin, Myung Hee and Ko, Kwan Soo and Son, Jun Seong and Chang, Hyun Ha and Kim, Shin Woo and Lee, Hyuck and Kim, Yeon Sook and Oh, Won Sup and Peck, Kyong Ran and Chongthaleong, Anan and Lalitha, Mukkai Kesavan and Perera, Jennifer and Yee, Ti Teow and Jamal, Farida and Kamarulzaman, Adeeba and Carlos, Celia Carpio and So, Thomas Man Kit (2004) Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens. Clinical Infectious Diseases, 38 (11). pp. 1570-1578. ISSN 1058-4838; ESSN: 1537-6591 http://cid.oxfordjournals.org/content/38/11/1570.abstract 10.1086/420821 |
| spellingShingle | Song, Jae Hoon Jung, Sook In Ki, Hyun Kyun Shin, Myung Hee Ko, Kwan Soo Son, Jun Seong Chang, Hyun Ha Kim, Shin Woo Lee, Hyuck Kim, Yeon Sook Oh, Won Sup Peck, Kyong Ran Chongthaleong, Anan Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Jamal, Farida Kamarulzaman, Adeeba Carlos, Celia Carpio So, Thomas Man Kit Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title | Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title_full | Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title_fullStr | Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title_full_unstemmed | Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title_short | Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian network for surveillance of resistant pathogens |
| title_sort | clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the asian network for surveillance of resistant pathogens |
| url | http://psasir.upm.edu.my/id/eprint/40244/ http://psasir.upm.edu.my/id/eprint/40244/ http://psasir.upm.edu.my/id/eprint/40244/ http://psasir.upm.edu.my/id/eprint/40244/1/Clinical%20outcomes%20of%20pneumococcal%20pneumonia%20caused%20by%20antibiotic-resistant%20strains%20in%20Asian%20countries.pdf |