In vitro inhibition of acetylcholinesterase by acephate and methamidophos
Inhibition of the acetylcholinesterase (AChE) of two insects, laboratory rat and human by acephate and methamidophos insecticides was evaluated in vitro. Acephate in itself is capable of inhibiting AChE to some extent, immediately as well as for a prolonged period. The inhibition by methamidophos pr...
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| Format: | Article |
| Language: | English |
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Malaysian Plant Protection Society
1990
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| Online Access: | http://psasir.upm.edu.my/id/eprint/39120/ http://psasir.upm.edu.my/id/eprint/39120/1/aar%20177%20In%20Vitro%20Inhibition%20Of%20Acetylcholinesterase%20By%20Acephate%20And.pdf |
| _version_ | 1848849058608709632 |
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| author | Mohamad, Rosli |
| author_facet | Mohamad, Rosli |
| author_sort | Mohamad, Rosli |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Inhibition of the acetylcholinesterase (AChE) of two insects, laboratory rat and human by acephate and methamidophos insecticides was evaluated in vitro. Acephate in itself is capable of inhibiting AChE to some extent, immediately as well as for a prolonged period. The inhibition by methamidophos progressed faster during the first 20 to 30 min of exposure, but not immediately. The pattern of inhibition of the AChE by both insecticides followed that of paraoxon, and are non-reversible. Incubation of AChE with acephate and methamidophos together did not produce inhibition of synergistic effect but could only be considered as additive |
| first_indexed | 2025-11-15T09:44:22Z |
| format | Article |
| id | upm-39120 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:44:22Z |
| publishDate | 1990 |
| publisher | Malaysian Plant Protection Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-391202016-01-11T07:05:13Z http://psasir.upm.edu.my/id/eprint/39120/ In vitro inhibition of acetylcholinesterase by acephate and methamidophos Mohamad, Rosli Inhibition of the acetylcholinesterase (AChE) of two insects, laboratory rat and human by acephate and methamidophos insecticides was evaluated in vitro. Acephate in itself is capable of inhibiting AChE to some extent, immediately as well as for a prolonged period. The inhibition by methamidophos progressed faster during the first 20 to 30 min of exposure, but not immediately. The pattern of inhibition of the AChE by both insecticides followed that of paraoxon, and are non-reversible. Incubation of AChE with acephate and methamidophos together did not produce inhibition of synergistic effect but could only be considered as additive Malaysian Plant Protection Society 1990 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/39120/1/aar%20177%20In%20Vitro%20Inhibition%20Of%20Acetylcholinesterase%20By%20Acephate%20And.pdf Mohamad, Rosli (1990) In vitro inhibition of acetylcholinesterase by acephate and methamidophos. Journal of Plant Protection in the Tropics, 7 (1). pp. 55-61. ISSN 0127-6883 |
| spellingShingle | Mohamad, Rosli In vitro inhibition of acetylcholinesterase by acephate and methamidophos |
| title | In vitro inhibition of acetylcholinesterase by acephate and
methamidophos
|
| title_full | In vitro inhibition of acetylcholinesterase by acephate and
methamidophos
|
| title_fullStr | In vitro inhibition of acetylcholinesterase by acephate and
methamidophos
|
| title_full_unstemmed | In vitro inhibition of acetylcholinesterase by acephate and
methamidophos
|
| title_short | In vitro inhibition of acetylcholinesterase by acephate and
methamidophos
|
| title_sort | in vitro inhibition of acetylcholinesterase by acephate and
methamidophos |
| url | http://psasir.upm.edu.my/id/eprint/39120/ http://psasir.upm.edu.my/id/eprint/39120/1/aar%20177%20In%20Vitro%20Inhibition%20Of%20Acetylcholinesterase%20By%20Acephate%20And.pdf |