Piper species: a comprehensive review on their phytochemistry, biological activities and applications
Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple c...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/38410/ http://psasir.upm.edu.my/id/eprint/38410/1/38410.pdf |
| _version_ | 1848848871757709312 |
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| author | Salehi, Bahare Zakaria, Zainul Amiruddin Gyawali, Rabin Ibrahim, Salam A. Rajkovic, Jovana Shinwari, Zabta Khan Khan, Tariq Sharifi-Rad, Javad Ozleyen, Adem Turkdonmez, Elif Valussi, Marco Tumer, Tugba Boyunegmez Fidalgo, Lianet Monzote Martorell, Miquel Setzer, William N. |
| author_facet | Salehi, Bahare Zakaria, Zainul Amiruddin Gyawali, Rabin Ibrahim, Salam A. Rajkovic, Jovana Shinwari, Zabta Khan Khan, Tariq Sharifi-Rad, Javad Ozleyen, Adem Turkdonmez, Elif Valussi, Marco Tumer, Tugba Boyunegmez Fidalgo, Lianet Monzote Martorell, Miquel Setzer, William N. |
| author_sort | Salehi, Bahare |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed. |
| first_indexed | 2025-11-15T09:41:23Z |
| format | Article |
| id | upm-38410 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:41:23Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-384102020-05-04T16:47:10Z http://psasir.upm.edu.my/id/eprint/38410/ Piper species: a comprehensive review on their phytochemistry, biological activities and applications Salehi, Bahare Zakaria, Zainul Amiruddin Gyawali, Rabin Ibrahim, Salam A. Rajkovic, Jovana Shinwari, Zabta Khan Khan, Tariq Sharifi-Rad, Javad Ozleyen, Adem Turkdonmez, Elif Valussi, Marco Tumer, Tugba Boyunegmez Fidalgo, Lianet Monzote Martorell, Miquel Setzer, William N. Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38410/1/38410.pdf Salehi, Bahare and Zakaria, Zainul Amiruddin and Gyawali, Rabin and Ibrahim, Salam A. and Rajkovic, Jovana and Shinwari, Zabta Khan and Khan, Tariq and Sharifi-Rad, Javad and Ozleyen, Adem and Turkdonmez, Elif and Valussi, Marco and Tumer, Tugba Boyunegmez and Fidalgo, Lianet Monzote and Martorell, Miquel and Setzer, William N. (2019) Piper species: a comprehensive review on their phytochemistry, biological activities and applications. Molecules, 24 (7). art. no. 1364. pp. 1-118. ISSN 1420-3049 https://www.mdpi.com/1420-3049/24/7/1364 10.3390/molecules24071364 |
| spellingShingle | Salehi, Bahare Zakaria, Zainul Amiruddin Gyawali, Rabin Ibrahim, Salam A. Rajkovic, Jovana Shinwari, Zabta Khan Khan, Tariq Sharifi-Rad, Javad Ozleyen, Adem Turkdonmez, Elif Valussi, Marco Tumer, Tugba Boyunegmez Fidalgo, Lianet Monzote Martorell, Miquel Setzer, William N. Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title | Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title_full | Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title_fullStr | Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title_full_unstemmed | Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title_short | Piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| title_sort | piper species: a comprehensive review on their phytochemistry, biological activities and applications |
| url | http://psasir.upm.edu.my/id/eprint/38410/ http://psasir.upm.edu.my/id/eprint/38410/ http://psasir.upm.edu.my/id/eprint/38410/ http://psasir.upm.edu.my/id/eprint/38410/1/38410.pdf |