Empowering mesenchymal stem cells for ocular degenerative disorders
Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic reti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/38403/ http://psasir.upm.edu.my/id/eprint/38403/1/38403.pdf |
| _version_ | 1848848869825183744 |
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| author | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Khan, Mohammed Safwan Ali Farhana, Aisha Mok, Pooi Ling |
| author_facet | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Khan, Mohammed Safwan Ali Farhana, Aisha Mok, Pooi Ling |
| author_sort | Ding, Shirley Suet Lee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and optic neuritis. Despite the known therapeutic role and mechanisms of MSCs, low cell precision towards the targeted area and cell survivability at tissue needing repair often resulted in a disparity in therapeutic outcomes. In this review, we will discuss the current and feasible strategy options to enhance treatment outcomes with MSC therapy. We will review the application of various types of biomaterials and advances in nanotechnology, which have been employed on MSCs to augment cellular function and differentiation for improving treatment of visual functions. In addition, several modes of gene delivery into MSCs and the types of associated therapeutic genes that are important for modulation of ocular tissue function and repair will be highlighted. |
| first_indexed | 2025-11-15T09:41:22Z |
| format | Article |
| id | upm-38403 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:41:22Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-384032020-05-04T16:28:51Z http://psasir.upm.edu.my/id/eprint/38403/ Empowering mesenchymal stem cells for ocular degenerative disorders Ding, Shirley Suet Lee Subbiah, Suresh Kumar Khan, Mohammed Safwan Ali Farhana, Aisha Mok, Pooi Ling Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and optic neuritis. Despite the known therapeutic role and mechanisms of MSCs, low cell precision towards the targeted area and cell survivability at tissue needing repair often resulted in a disparity in therapeutic outcomes. In this review, we will discuss the current and feasible strategy options to enhance treatment outcomes with MSC therapy. We will review the application of various types of biomaterials and advances in nanotechnology, which have been employed on MSCs to augment cellular function and differentiation for improving treatment of visual functions. In addition, several modes of gene delivery into MSCs and the types of associated therapeutic genes that are important for modulation of ocular tissue function and repair will be highlighted. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38403/1/38403.pdf Ding, Shirley Suet Lee and Subbiah, Suresh Kumar and Khan, Mohammed Safwan Ali and Farhana, Aisha and Mok, Pooi Ling (2019) Empowering mesenchymal stem cells for ocular degenerative disorders. International Journal of Molecular Sciences, 20 (7). art. no. 1784. pp. 1-13. ISSN 1661-6596; ESSN: 1422-0067 https://www.mdpi.com/1422-0067/20/7/1784 10.3390/ijms20071784 |
| spellingShingle | Ding, Shirley Suet Lee Subbiah, Suresh Kumar Khan, Mohammed Safwan Ali Farhana, Aisha Mok, Pooi Ling Empowering mesenchymal stem cells for ocular degenerative disorders |
| title | Empowering mesenchymal stem cells for ocular degenerative disorders |
| title_full | Empowering mesenchymal stem cells for ocular degenerative disorders |
| title_fullStr | Empowering mesenchymal stem cells for ocular degenerative disorders |
| title_full_unstemmed | Empowering mesenchymal stem cells for ocular degenerative disorders |
| title_short | Empowering mesenchymal stem cells for ocular degenerative disorders |
| title_sort | empowering mesenchymal stem cells for ocular degenerative disorders |
| url | http://psasir.upm.edu.my/id/eprint/38403/ http://psasir.upm.edu.my/id/eprint/38403/ http://psasir.upm.edu.my/id/eprint/38403/ http://psasir.upm.edu.my/id/eprint/38403/1/38403.pdf |