Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer

QR Code

Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer

While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in...

Full description

Bibliographic Details
Main Authors:	Paulraj, Felicia Simone, Abas, Faridah, Lajis, Nordin, Othman, Iekhsan, Naidu, Rakesh
Format:	Article
Language:	English
Published:	MDPI 2019
Online Access:	http://psasir.upm.edu.my/id/eprint/38331/ http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf

Similar Items

Identification of commonly regulated genes in HPV18- and HPV16-infected cervical cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one
by: Paulraj, Felicia, et al.
Published: (2018)

The curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 and HPV18-infected cervical cancer cells
by: Paulraj, Felicia, et al.
Published: (2015)

Mechanism of apoptosis induced by curcumin in colorectal cancer
by: Ismail, Nor Isnida, et al.
Published: (2019)

Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)

Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer
by: Abd. Wahab, Nurul Azwa, et al.
Published: (2020)

Mechanistic understanding of curcumin's therapeutic effects in lung cancer
by: Wan Mohd Tajuddin, Wan Nur Baitty, et al.
Published: (2019)

Mechanistic understanding of curcumin’s therapeutic effects in lung cancer
by: Wan Mohd Tajuddin, Wan Nur Baitty, et al.
Published: (2019)

Diarylpentanoid (1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one) (MS13) exhibits anti-proliferative, apoptosis induction and anti-migration properties on androgen-independent human prostate cancer by targeting cell cycle-apoptosis and PI3K signalling pathways
by: Abd Wahab, Nurul Azwa, et al.
Published: (2021)

Anti-cancer mechanisms of diarylpentanoid MS17 (1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one) in human colon cancer cells: a proteomics approach
by: Hon, Kha Wai, et al.
Published: (2024)

Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015)

Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro
by: Lee, Ka Heng, et al.
Published: (2015)

Anti-proliferative effect and induction of apoptosis in androgen-independent human prostate cancer cells by 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one
by: Citalingam, Kamini, et al.
Published: (2015)

Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation
by: Liew, Kong Yen, et al.
Published: (2019)

Toxicity evaluation of curcumin analogue on zebrafish
by: Tan, Hong Wei
Published: (2015)

The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
by: Hui, Ming Ong, et al.
Published: (2021)

A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
by: Liew, Kong Yen, et al.
Published: (2024)

Molecular mechanisms of antiproliferative and apoptosis activity by 1,5-bis(4-hydroxy-3 methoxyphenyl) 1,4-pentadiene-3-one (ms13) on human non-small cell lung cancer cells
by: Wan Mohd Tajuddin, Wan Nur Baitty, et al.
Published: (2021)

In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
by: Leong, Sze Wei, et al.
Published: (2018)

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues
by: Yakubu, Ndatsu
Published: (2015)

In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against LoVo colorectal cancer cells
by: Leong, Sze Wei, et al.
Published: (2020)

Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic applications
by: Basheer, Abdul Samad, et al.
Published: (2021)

Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice
by: Ong, Hui Ming, et al.
Published: (2021)

Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models
by: Choo, Brandon Kar Meng, et al.
Published: (2021)

Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016)

BDMC33, a curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways
by: Lee, Ka Heng, et al.
Published: (2012)

Exploring flavour generation pathways in plant-based meat analogues
by: Plant, Alexandra
Published: (2025)

Synthesis of damnacanthal, a naturally occurring 9,10-anthraquinone and its analogues, and its biological evaluation against five cancer cell lines.
by: Saha, Koushik, et al.
Published: (2013)

Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway
by: Khaled bin Break, Mohammed, et al.
Published: (2018)

The multifaceted role of curcumin in cancer prevention and treatment
by: Shanmugam, M., et al.
Published: (2015)

Curcumin combination chemotherapy: the implication and efficacy in cancer
by: Tan, Bee Ling, et al.
Published: (2019)

Curcumin combination therapy: the implication and efficacy in cancer
by: Bee, Ling Tan, et al.
Published: (2019)

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2016)

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2016)

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)

Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY
by: Buhrmann, Constanze, et al.
Published: (2011)

Toxicity effects of curcumin analogue, 2, 6-BIS (2-fluorobenzylidene) cyclohexanone on zebrafish (Danio rerio F. Hamilton, 1822)
by: Nazarudin, Nur Amiza
Published: (2017)