Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians
Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. The lower intake of α-linolenic acid (ALA) than linoleic acid (LA) among vegetarians may disrupt the fatty acid metabolism and limit the conversion of ALA to anti-inflammatory products such as eicosape...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/38294/ http://psasir.upm.edu.my/id/eprint/38294/1/38294.pdf |
| _version_ | 1848848839760412672 |
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| author | Ching, Yuan Kei Chin, Yit Siew Appukutty, Mahenderan Ramachandran, Vasudevan Yu, Choo Yee Ang, Geik Yong Gan, Wan Ying Chan, Yoke Mun Teh, Lay Kek Salleh, Mohd Zaki |
| author_facet | Ching, Yuan Kei Chin, Yit Siew Appukutty, Mahenderan Ramachandran, Vasudevan Yu, Choo Yee Ang, Geik Yong Gan, Wan Ying Chan, Yoke Mun Teh, Lay Kek Salleh, Mohd Zaki |
| author_sort | Ching, Yuan Kei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. The lower intake of α-linolenic acid (ALA) than linoleic acid (LA) among vegetarians may disrupt the fatty acid metabolism and limit the conversion of ALA to anti-inflammatory products such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This cross-sectional study aimed to determine the interaction of rs174547 in FADS1 gene with LA and ALA on metabolic syndrome (MetS) components. A total of 200 Chinese and Indian vegetarians in Kuala Lumpur and Selangor, Malaysia participated in the present study. The data on socio-demographic characteristics, vegetarianism practices, dietary practices, anthropometric measurements, blood pressure (BP), and overnight venous fasting blood samples were collected from the vegetarians. The rs174547 in FADS1 gene was significantly associated with MetS and its components such as waist circumference (WC) and fasting blood glucose (FBG). Multiple logistic regression analyses revealed that vegetarians with TT genotype of rs174547 in FADS1 gene had higher odds for MetS, larger WC, higher BP, and a lower level of HDL-c. Two-way ANOVA analysis showed that LA interacts with rs174547 in FADS1 gene to affect HDL-c (p < 0.05) among vegetarians. The present findings suggest the need to develop dietary guidelines for vegetarians in Malaysia. Prospective studies are also needed to affirm the interaction between LA and rs174547 in FADS1 gene on HDL-c among Malaysian vegetarians. |
| first_indexed | 2025-11-15T09:40:53Z |
| format | Article |
| id | upm-38294 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:40:53Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-382942020-05-04T16:13:04Z http://psasir.upm.edu.my/id/eprint/38294/ Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians Ching, Yuan Kei Chin, Yit Siew Appukutty, Mahenderan Ramachandran, Vasudevan Yu, Choo Yee Ang, Geik Yong Gan, Wan Ying Chan, Yoke Mun Teh, Lay Kek Salleh, Mohd Zaki Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body. The lower intake of α-linolenic acid (ALA) than linoleic acid (LA) among vegetarians may disrupt the fatty acid metabolism and limit the conversion of ALA to anti-inflammatory products such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This cross-sectional study aimed to determine the interaction of rs174547 in FADS1 gene with LA and ALA on metabolic syndrome (MetS) components. A total of 200 Chinese and Indian vegetarians in Kuala Lumpur and Selangor, Malaysia participated in the present study. The data on socio-demographic characteristics, vegetarianism practices, dietary practices, anthropometric measurements, blood pressure (BP), and overnight venous fasting blood samples were collected from the vegetarians. The rs174547 in FADS1 gene was significantly associated with MetS and its components such as waist circumference (WC) and fasting blood glucose (FBG). Multiple logistic regression analyses revealed that vegetarians with TT genotype of rs174547 in FADS1 gene had higher odds for MetS, larger WC, higher BP, and a lower level of HDL-c. Two-way ANOVA analysis showed that LA interacts with rs174547 in FADS1 gene to affect HDL-c (p < 0.05) among vegetarians. The present findings suggest the need to develop dietary guidelines for vegetarians in Malaysia. Prospective studies are also needed to affirm the interaction between LA and rs174547 in FADS1 gene on HDL-c among Malaysian vegetarians. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38294/1/38294.pdf Ching, Yuan Kei and Chin, Yit Siew and Appukutty, Mahenderan and Ramachandran, Vasudevan and Yu, Choo Yee and Ang, Geik Yong and Gan, Wan Ying and Chan, Yoke Mun and Teh, Lay Kek and Salleh, Mohd Zaki (2019) Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians. Nutrients, 11 (7). art. no. 1686. pp. 1-16. ISSN 2072-6643 https://www.mdpi.com/2072-6643/11/7/1686 10.3390/nu11071686 |
| spellingShingle | Ching, Yuan Kei Chin, Yit Siew Appukutty, Mahenderan Ramachandran, Vasudevan Yu, Choo Yee Ang, Geik Yong Gan, Wan Ying Chan, Yoke Mun Teh, Lay Kek Salleh, Mohd Zaki Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title | Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title_full | Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title_fullStr | Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title_full_unstemmed | Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title_short | Interaction of dietary linoleic acid and α-linolenic acids with rs174547 in FADS1 gene on metabolic syndrome components among vegetarians |
| title_sort | interaction of dietary linoleic acid and α-linolenic acids with rs174547 in fads1 gene on metabolic syndrome components among vegetarians |
| url | http://psasir.upm.edu.my/id/eprint/38294/ http://psasir.upm.edu.my/id/eprint/38294/ http://psasir.upm.edu.my/id/eprint/38294/ http://psasir.upm.edu.my/id/eprint/38294/1/38294.pdf |