Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/38214/ http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf |
| _version_ | 1848848817491804160 |
|---|---|
| author | Lee, Kai Wei Ching, Siew Mooi Ramachandran, Vasudevan Tusimin, Maiza Mohd Nordin, Noraihan Chong, Seng Choi Hoo, Fan Kee |
| author_facet | Lee, Kai Wei Ching, Siew Mooi Ramachandran, Vasudevan Tusimin, Maiza Mohd Nordin, Noraihan Chong, Seng Choi Hoo, Fan Kee |
| author_sort | Lee, Kai Wei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms. |
| first_indexed | 2025-11-15T09:40:32Z |
| format | Article |
| id | upm-38214 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:40:32Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-382142020-05-04T15:58:51Z http://psasir.upm.edu.my/id/eprint/38214/ Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus Lee, Kai Wei Ching, Siew Mooi Ramachandran, Vasudevan Tusimin, Maiza Mohd Nordin, Noraihan Chong, Seng Choi Hoo, Fan Kee The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf Lee, Kai Wei and Ching, Siew Mooi and Ramachandran, Vasudevan and Tusimin, Maiza and Mohd Nordin, Noraihan and Chong, Seng Choi and Hoo, Fan Kee (2019) Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus. Genes, 10 (12). art. no. 988. pp. 1-20. ISSN 2073-4425 https://www.mdpi.com/2073-4425/10/12/988 10.3390/genes10120988 |
| spellingShingle | Lee, Kai Wei Ching, Siew Mooi Ramachandran, Vasudevan Tusimin, Maiza Mohd Nordin, Noraihan Chong, Seng Choi Hoo, Fan Kee Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title | Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title_full | Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title_fullStr | Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title_full_unstemmed | Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title_short | Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| title_sort | association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus |
| url | http://psasir.upm.edu.my/id/eprint/38214/ http://psasir.upm.edu.my/id/eprint/38214/ http://psasir.upm.edu.my/id/eprint/38214/ http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf |