Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone
A physical and chemically stable palm kernel oil esters emulsion system with nanosized droplet was developed as a delivery system for hydrocortisone (hydrophobic drug). A simple low energy emulsification method was used in forming the nanoemulsions. The influence of added solvents (isopropanol and e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Chemic Publishing Company
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37703/ http://psasir.upm.edu.my/id/eprint/37703/1/Formation%20of%20stable%20palm%20kernel%20oil%20esters%20nanoemulsion%20system%20containing%20hydrocortisone.pdf |
| _version_ | 1848848679279001600 |
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| author | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon |
| author_facet | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon |
| author_sort | Da Costa, Stephanie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A physical and chemically stable palm kernel oil esters emulsion system with nanosized droplet was developed as a delivery system for hydrocortisone (hydrophobic drug). A simple low energy emulsification method was used in forming the nanoemulsions. The influence of added solvents (isopropanol and ethanol) on particle size and stability of oil in water nanoemulsion was investigated. Formation of nanoemulsion with solvent, increase the solubility of hydrocortisone in the oil phase and thus make the nanoemulsion more stable. Reducing the solvent to lipoid ratio showed no significant difference in the mean particle size. However, after solvent removal particle size increased over time. As for zeta potential value, all nanoemulsions exhibited values below -30 mV which indicated good stability. The DSC thermograms for stable nanoemulsions proved that hydrocortisone is in a non-crystalline state, suggesting that hydrocortisone is homogenized well in the nanoemulsion system. These results showed that nanoemulsion with solvent appear to be a promising transdermal delivery vehicle for hydrocortisone. |
| first_indexed | 2025-11-15T09:38:20Z |
| format | Article |
| id | upm-37703 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:38:20Z |
| publishDate | 2014 |
| publisher | Chemic Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-377032015-10-06T04:10:59Z http://psasir.upm.edu.my/id/eprint/37703/ Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon A physical and chemically stable palm kernel oil esters emulsion system with nanosized droplet was developed as a delivery system for hydrocortisone (hydrophobic drug). A simple low energy emulsification method was used in forming the nanoemulsions. The influence of added solvents (isopropanol and ethanol) on particle size and stability of oil in water nanoemulsion was investigated. Formation of nanoemulsion with solvent, increase the solubility of hydrocortisone in the oil phase and thus make the nanoemulsion more stable. Reducing the solvent to lipoid ratio showed no significant difference in the mean particle size. However, after solvent removal particle size increased over time. As for zeta potential value, all nanoemulsions exhibited values below -30 mV which indicated good stability. The DSC thermograms for stable nanoemulsions proved that hydrocortisone is in a non-crystalline state, suggesting that hydrocortisone is homogenized well in the nanoemulsion system. These results showed that nanoemulsion with solvent appear to be a promising transdermal delivery vehicle for hydrocortisone. Chemic Publishing Company 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37703/1/Formation%20of%20stable%20palm%20kernel%20oil%20esters%20nanoemulsion%20system%20containing%20hydrocortisone.pdf Da Costa, Stephanie and Basri, Mahiran and Shamsudin, Norashikin and Basri, Hamidon (2014) Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone. Asian Journal of Chemistry, 26 (10). pp. 2883-2888. ISSN 0970-7077; ESSN: 0975-427X http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_11_16 10.14233/ajchem.2014.15929 |
| spellingShingle | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title | Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title_full | Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title_fullStr | Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title_full_unstemmed | Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title_short | Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| title_sort | formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone |
| url | http://psasir.upm.edu.my/id/eprint/37703/ http://psasir.upm.edu.my/id/eprint/37703/ http://psasir.upm.edu.my/id/eprint/37703/ http://psasir.upm.edu.my/id/eprint/37703/1/Formation%20of%20stable%20palm%20kernel%20oil%20esters%20nanoemulsion%20system%20containing%20hydrocortisone.pdf |