Extended spectrum beta-lactamases: definition, classification and epidemiology
Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective o...
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| Language: | English |
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Caister Academic Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37589/ http://psasir.upm.edu.my/id/eprint/37589/1/Extended%20spectrum%20beta-lactamases%20definition%2C%20classification%20and%20epidemiology.pdf |
| _version_ | 1848848648041922560 |
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| author | Ghafourian, Sobhan Sadeghifard, Nourkhoda Soheili, Sara Sekawi, Zamberi |
| author_facet | Ghafourian, Sobhan Sadeghifard, Nourkhoda Soheili, Sara Sekawi, Zamberi |
| author_sort | Ghafourian, Sobhan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains. Globally, ESBLs are considered to be problematic, particularly in hospitalized patients. There is an increasing frequency of ESBL in different parts of the world. The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients. Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence. |
| first_indexed | 2025-11-15T09:37:50Z |
| format | Article |
| id | upm-37589 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:37:50Z |
| publishDate | 2015 |
| publisher | Caister Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-375892015-12-18T01:52:24Z http://psasir.upm.edu.my/id/eprint/37589/ Extended spectrum beta-lactamases: definition, classification and epidemiology Ghafourian, Sobhan Sadeghifard, Nourkhoda Soheili, Sara Sekawi, Zamberi Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains. Globally, ESBLs are considered to be problematic, particularly in hospitalized patients. There is an increasing frequency of ESBL in different parts of the world. The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients. Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence. Caister Academic Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37589/1/Extended%20spectrum%20beta-lactamases%20definition%2C%20classification%20and%20epidemiology.pdf Ghafourian, Sobhan and Sadeghifard, Nourkhoda and Soheili, Sara and Sekawi, Zamberi (2015) Extended spectrum beta-lactamases: definition, classification and epidemiology. Current Issues in Molecular Biology, 17. pp. 11-22. ISSN 1467-3037; ESSN: 1467-3045 http://www.horizonpress.com/cimb/abstracts/v17/11.html |
| spellingShingle | Ghafourian, Sobhan Sadeghifard, Nourkhoda Soheili, Sara Sekawi, Zamberi Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title | Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title_full | Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title_fullStr | Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title_full_unstemmed | Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title_short | Extended spectrum beta-lactamases: definition, classification and epidemiology |
| title_sort | extended spectrum beta-lactamases: definition, classification and epidemiology |
| url | http://psasir.upm.edu.my/id/eprint/37589/ http://psasir.upm.edu.my/id/eprint/37589/ http://psasir.upm.edu.my/id/eprint/37589/1/Extended%20spectrum%20beta-lactamases%20definition%2C%20classification%20and%20epidemiology.pdf |