Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children
Children are the vulnerable group in the agricultural community due to their early exposure to pesticides through the dynamic interplay between genetic predisposition, environment, and host-related factors. This study aims to identify the possible association between the depression in blood cholines...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37566/ http://psasir.upm.edu.my/id/eprint/37566/1/37566.pdf |
| _version_ | 1848848641411776512 |
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| author | How, Vivien Hashim, Zailina Ismail, Patimah Md Said, Salmiah Omar, Dzolkhifli Mohd Tamrin, Shamsul Bahri |
| author_facet | How, Vivien Hashim, Zailina Ismail, Patimah Md Said, Salmiah Omar, Dzolkhifli Mohd Tamrin, Shamsul Bahri |
| author_sort | How, Vivien |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Children are the vulnerable group in the agricultural community due to their early exposure to pesticides through the dynamic interplay between genetic predisposition, environment, and host-related factors. This study aims to identify the possible association between the depression in blood cholinesterase level and genotoxic effect among farm children. The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. These genotoxicity end points suggest that farm children's cells experience early DNA damage that may lead to uncontrolled cell proliferation during their adulthood. Thus, farm children who grow up near pesticide-treated farmland have a higher probability of developing cancer than children with minimal or zero exposure to pesticides. |
| first_indexed | 2025-11-15T09:37:44Z |
| format | Article |
| id | upm-37566 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:37:44Z |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-375662016-04-22T03:29:07Z http://psasir.upm.edu.my/id/eprint/37566/ Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children How, Vivien Hashim, Zailina Ismail, Patimah Md Said, Salmiah Omar, Dzolkhifli Mohd Tamrin, Shamsul Bahri Children are the vulnerable group in the agricultural community due to their early exposure to pesticides through the dynamic interplay between genetic predisposition, environment, and host-related factors. This study aims to identify the possible association between the depression in blood cholinesterase level and genotoxic effect among farm children. The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. These genotoxicity end points suggest that farm children's cells experience early DNA damage that may lead to uncontrolled cell proliferation during their adulthood. Thus, farm children who grow up near pesticide-treated farmland have a higher probability of developing cancer than children with minimal or zero exposure to pesticides. Taylor & Francis 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37566/1/37566.pdf How, Vivien and Hashim, Zailina and Ismail, Patimah and Md Said, Salmiah and Omar, Dzolkhifli and Mohd Tamrin, Shamsul Bahri (2014) Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children. Journal of Agromedicine, 19 (1). pp. 35-43. ISSN 1059-924X; ESSN: 1545-0813 http://www.tandfonline.com/doi/abs/10.1080/1059924X.2013.866917 10.1080/1059924X.2013.866917 |
| spellingShingle | How, Vivien Hashim, Zailina Ismail, Patimah Md Said, Salmiah Omar, Dzolkhifli Mohd Tamrin, Shamsul Bahri Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title | Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title_full | Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title_fullStr | Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title_full_unstemmed | Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title_short | Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| title_sort | exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children |
| url | http://psasir.upm.edu.my/id/eprint/37566/ http://psasir.upm.edu.my/id/eprint/37566/ http://psasir.upm.edu.my/id/eprint/37566/ http://psasir.upm.edu.my/id/eprint/37566/1/37566.pdf |