Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus
Background: Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses. Methods: Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37281/ http://psasir.upm.edu.my/id/eprint/37281/1/Effect%20of%20Nigella%20sativa%20fixed%20and%20essential%20oils%20on.pdf |
| _version_ | 1848848566806642688 |
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| author | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Iqbal, Shahzad Zafar Ahmad, Shakeel Zia-Ul-Haq, Muhammad Aliberti, Luigi Ahmad, Atif Nisar De Feo, Vincenzo |
| author_facet | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Iqbal, Shahzad Zafar Ahmad, Shakeel Zia-Ul-Haq, Muhammad Aliberti, Luigi Ahmad, Atif Nisar De Feo, Vincenzo |
| author_sort | Sultan, Muhammad Tauseef |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses. Methods: Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant potential, oxidative stress, and the immunity by in vivo experiments. Results: The results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of the nitric oxide production thus controlling the diabetes complications. Conclusions: Overall, results of present study supported the traditional use of N. sativa and its derived products as a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications. |
| first_indexed | 2025-11-15T09:36:33Z |
| format | Article |
| id | upm-37281 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:36:33Z |
| publishDate | 2014 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-372812015-09-07T10:44:13Z http://psasir.upm.edu.my/id/eprint/37281/ Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Iqbal, Shahzad Zafar Ahmad, Shakeel Zia-Ul-Haq, Muhammad Aliberti, Luigi Ahmad, Atif Nisar De Feo, Vincenzo Background: Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses. Methods: Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant potential, oxidative stress, and the immunity by in vivo experiments. Results: The results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of the nitric oxide production thus controlling the diabetes complications. Conclusions: Overall, results of present study supported the traditional use of N. sativa and its derived products as a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications. BioMed Central 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37281/1/Effect%20of%20Nigella%20sativa%20fixed%20and%20essential%20oils%20on.pdf Sultan, Muhammad Tauseef and Butt, Masood Sadiq and Karim, Roselina and Iqbal, Shahzad Zafar and Ahmad, Shakeel and Zia-Ul-Haq, Muhammad and Aliberti, Luigi and Ahmad, Atif Nisar and De Feo, Vincenzo (2014) Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus. BMC Complementary and Alternative Medicine, 14. art. no. 193. pp. 1-7. ISSN 1472-6882 http://www.biomedcentral.com/1472-6882/14/193/abstract 10.1186/1472-6882-14-193 |
| spellingShingle | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Iqbal, Shahzad Zafar Ahmad, Shakeel Zia-Ul-Haq, Muhammad Aliberti, Luigi Ahmad, Atif Nisar De Feo, Vincenzo Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title | Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title_full | Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title_fullStr | Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title_full_unstemmed | Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title_short | Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| title_sort | effect of nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus |
| url | http://psasir.upm.edu.my/id/eprint/37281/ http://psasir.upm.edu.my/id/eprint/37281/ http://psasir.upm.edu.my/id/eprint/37281/ http://psasir.upm.edu.my/id/eprint/37281/1/Effect%20of%20Nigella%20sativa%20fixed%20and%20essential%20oils%20on.pdf |