Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats
The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive co...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Pharmacy, University of Karachi
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/37204/ http://psasir.upm.edu.my/id/eprint/37204/1/Effect%20of%20aqueous%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol%20and%20carbon%20tetrachloride.pdf |
| _version_ | 1848848545717682176 |
|---|---|
| author | Ismail, Noor Aisyah Shamsahal Din, Nor Syafawati Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Kamisan, Farah Hidayah Yahya, Farhana Mohtarrudin, Norhafizah Mohd Desa, Mohd Nasir Zakaria, Zainul Amiruddin |
| author_facet | Ismail, Noor Aisyah Shamsahal Din, Nor Syafawati Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Kamisan, Farah Hidayah Yahya, Farhana Mohtarrudin, Norhafizah Mohd Desa, Mohd Nasir Zakaria, Zainul Amiruddin |
| author_sort | Ismail, Noor Aisyah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (p<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (p<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted. |
| first_indexed | 2025-11-15T09:36:12Z |
| format | Article |
| id | upm-37204 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:36:12Z |
| publishDate | 2014 |
| publisher | Faculty of Pharmacy, University of Karachi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-372042015-09-17T06:40:43Z http://psasir.upm.edu.my/id/eprint/37204/ Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats Ismail, Noor Aisyah Shamsahal Din, Nor Syafawati Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Kamisan, Farah Hidayah Yahya, Farhana Mohtarrudin, Norhafizah Mohd Desa, Mohd Nasir Zakaria, Zainul Amiruddin The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (p<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (p<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted. Faculty of Pharmacy, University of Karachi 2014-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37204/1/Effect%20of%20aqueous%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol%20and%20carbon%20tetrachloride.pdf Ismail, Noor Aisyah and Shamsahal Din, Nor Syafawati and Mamat, Siti Syariah and Zabidi, Zalina and Wan Zainulddin, Wan Noraziemah and Kamisan, Farah Hidayah and Yahya, Farhana and Mohtarrudin, Norhafizah and Mohd Desa, Mohd Nasir and Zakaria, Zainul Amiruddin (2014) Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats. Pakistan Journal of Pharmaceutical Sciences, 27 (4). pp. 831-835. ISSN 1011-601X http://www.pjps.pk/?page_id=258 |
| spellingShingle | Ismail, Noor Aisyah Shamsahal Din, Nor Syafawati Mamat, Siti Syariah Zabidi, Zalina Wan Zainulddin, Wan Noraziemah Kamisan, Farah Hidayah Yahya, Farhana Mohtarrudin, Norhafizah Mohd Desa, Mohd Nasir Zakaria, Zainul Amiruddin Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title_full | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title_fullStr | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title_full_unstemmed | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title_short | Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| title_sort | effect of aqueous extract of dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats |
| url | http://psasir.upm.edu.my/id/eprint/37204/ http://psasir.upm.edu.my/id/eprint/37204/ http://psasir.upm.edu.my/id/eprint/37204/1/Effect%20of%20aqueous%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol%20and%20carbon%20tetrachloride.pdf |