Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold
A novel porous three-dimensional bone scaffold was developed using a natural polymer (alginate/Alg) in combination with a naturally obtained biomineral (nano cockle shell powder/nCP) through lyophilization techniques. The scaffold was developed in varying composition mixture of Alg-nCP and character...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37048/ http://psasir.upm.edu.my/id/eprint/37048/1/Development%20and%20characterization%20of%20novel%20porous%203D%20alginate.pdf |
| _version_ | 1848848503277617152 |
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| author | Bharatham, B. Hemabarathy Abu Bakar @ Zakaria, Md Zuki Perimal, Enoch Kumar Mohamad Yusof, Loqman Hamid, Muhajir |
| author_facet | Bharatham, B. Hemabarathy Abu Bakar @ Zakaria, Md Zuki Perimal, Enoch Kumar Mohamad Yusof, Loqman Hamid, Muhajir |
| author_sort | Bharatham, B. Hemabarathy |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A novel porous three-dimensional bone scaffold was developed using a natural polymer (alginate/Alg) in combination with a naturally obtained biomineral (nano cockle shell powder/nCP) through lyophilization techniques. The scaffold was developed in varying composition mixture of Alg-nCP and characterized using various evaluation techniques as well as preliminary in vitro studies on MG63 human osteoblast cells. Morphological observations using SEM revealed variations in structures with the use of different Alg-nCP composition ratios. All the developed scaffolds showed a porous structure with pore sizes ideal for facilitating new bone growth; however, not all combination mixtures showed subsequent favorable characteristics to be used for biological applications. Scaffolds produced using the combination mixture of 40% Alg and 60% nCP produced significantly promising results in terms of mechanical strength, degradation rate, and increased cell proliferation rates making it potentially the optimum composition mixture of Alg-nCP with future application prospects. |
| first_indexed | 2025-11-15T09:35:32Z |
| format | Article |
| id | upm-37048 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:35:32Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-370482016-11-21T03:08:22Z http://psasir.upm.edu.my/id/eprint/37048/ Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold Bharatham, B. Hemabarathy Abu Bakar @ Zakaria, Md Zuki Perimal, Enoch Kumar Mohamad Yusof, Loqman Hamid, Muhajir A novel porous three-dimensional bone scaffold was developed using a natural polymer (alginate/Alg) in combination with a naturally obtained biomineral (nano cockle shell powder/nCP) through lyophilization techniques. The scaffold was developed in varying composition mixture of Alg-nCP and characterized using various evaluation techniques as well as preliminary in vitro studies on MG63 human osteoblast cells. Morphological observations using SEM revealed variations in structures with the use of different Alg-nCP composition ratios. All the developed scaffolds showed a porous structure with pore sizes ideal for facilitating new bone growth; however, not all combination mixtures showed subsequent favorable characteristics to be used for biological applications. Scaffolds produced using the combination mixture of 40% Alg and 60% nCP produced significantly promising results in terms of mechanical strength, degradation rate, and increased cell proliferation rates making it potentially the optimum composition mixture of Alg-nCP with future application prospects. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37048/1/Development%20and%20characterization%20of%20novel%20porous%203D%20alginate.pdf Bharatham, B. Hemabarathy and Abu Bakar @ Zakaria, Md Zuki and Perimal, Enoch Kumar and Mohamad Yusof, Loqman and Hamid, Muhajir (2014) Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold. BioMed Research International, 2014. art. no. 146723. pp. 1-11. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/146723/abs/ 10.1155/2014/146723 |
| spellingShingle | Bharatham, B. Hemabarathy Abu Bakar @ Zakaria, Md Zuki Perimal, Enoch Kumar Mohamad Yusof, Loqman Hamid, Muhajir Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title | Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title_full | Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title_fullStr | Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title_full_unstemmed | Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title_short | Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold |
| title_sort | development and characterization of novel porous 3d alginate-cockle shell powder nanobiocomposite bone scaffold |
| url | http://psasir.upm.edu.my/id/eprint/37048/ http://psasir.upm.edu.my/id/eprint/37048/ http://psasir.upm.edu.my/id/eprint/37048/ http://psasir.upm.edu.my/id/eprint/37048/1/Development%20and%20characterization%20of%20novel%20porous%203D%20alginate.pdf |