Comparative aspects of microRNA expression in canine and human cancers
MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs tha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Veterinary Science
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37000/ http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf |
| _version_ | 1848848490550001664 |
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| author | Sahabi, Kabiru Selvarajah, Gayathri Thevi Abdullah, Rasedee Cheah, Yoke Kqueen Tan, Geok Chin |
| author_facet | Sahabi, Kabiru Selvarajah, Gayathri Thevi Abdullah, Rasedee Cheah, Yoke Kqueen Tan, Geok Chin |
| author_sort | Sahabi, Kabiru |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed. |
| first_indexed | 2025-11-15T09:35:20Z |
| format | Article |
| id | upm-37000 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:35:20Z |
| publishDate | 2018 |
| publisher | The Korean Society of Veterinary Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-370002020-07-06T03:14:10Z http://psasir.upm.edu.my/id/eprint/37000/ Comparative aspects of microRNA expression in canine and human cancers Sahabi, Kabiru Selvarajah, Gayathri Thevi Abdullah, Rasedee Cheah, Yoke Kqueen Tan, Geok Chin MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed. The Korean Society of Veterinary Science 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf Sahabi, Kabiru and Selvarajah, Gayathri Thevi and Abdullah, Rasedee and Cheah, Yoke Kqueen and Tan, Geok Chin (2018) Comparative aspects of microRNA expression in canine and human cancers. Journal of Veterinary Science, 19 (2). pp. 162-171. ISSN 1229-845X; ESSN: 1976-555X https://vetsci.org/search.php?where=aview&id=10.4142/jvs.2018.19.2.162&code=0118JVS&vmode=AONLY# 10.4142/jvs.2018.19.2.162 |
| spellingShingle | Sahabi, Kabiru Selvarajah, Gayathri Thevi Abdullah, Rasedee Cheah, Yoke Kqueen Tan, Geok Chin Comparative aspects of microRNA expression in canine and human cancers |
| title | Comparative aspects of microRNA expression in canine and human cancers |
| title_full | Comparative aspects of microRNA expression in canine and human cancers |
| title_fullStr | Comparative aspects of microRNA expression in canine and human cancers |
| title_full_unstemmed | Comparative aspects of microRNA expression in canine and human cancers |
| title_short | Comparative aspects of microRNA expression in canine and human cancers |
| title_sort | comparative aspects of microrna expression in canine and human cancers |
| url | http://psasir.upm.edu.my/id/eprint/37000/ http://psasir.upm.edu.my/id/eprint/37000/ http://psasir.upm.edu.my/id/eprint/37000/ http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf |