Understanding glioblastoma biomarkers: knocking a mountain with a hammer
Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36976/ http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf |
| _version_ | 1848848483564388352 |
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| author | Mesrati, Malak Hassn Behrooz, Amir Barzegar Abuhamad, Asmaa Y. Amir Hamzah, Amir Syahir |
| author_facet | Mesrati, Malak Hassn Behrooz, Amir Barzegar Abuhamad, Asmaa Y. Amir Hamzah, Amir Syahir |
| author_sort | Mesrati, Malak Hassn |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways. |
| first_indexed | 2025-11-15T09:35:13Z |
| format | Article |
| id | upm-36976 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:35:13Z |
| publishDate | 2020 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-369762020-06-16T06:39:32Z http://psasir.upm.edu.my/id/eprint/36976/ Understanding glioblastoma biomarkers: knocking a mountain with a hammer Mesrati, Malak Hassn Behrooz, Amir Barzegar Abuhamad, Asmaa Y. Amir Hamzah, Amir Syahir Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf Mesrati, Malak Hassn and Behrooz, Amir Barzegar and Abuhamad, Asmaa Y. and Amir Hamzah, Amir Syahir (2020) Understanding glioblastoma biomarkers: knocking a mountain with a hammer. Cells, 9 (5). art. no. 1236. pp. 1-18. ISSN 2073-4409 https://www.mdpi.com/2073-4409/9/5/1236 10.3390/cells9051236 |
| spellingShingle | Mesrati, Malak Hassn Behrooz, Amir Barzegar Abuhamad, Asmaa Y. Amir Hamzah, Amir Syahir Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title | Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title_full | Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title_fullStr | Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title_full_unstemmed | Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title_short | Understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| title_sort | understanding glioblastoma biomarkers: knocking a mountain with a hammer |
| url | http://psasir.upm.edu.my/id/eprint/36976/ http://psasir.upm.edu.my/id/eprint/36976/ http://psasir.upm.edu.my/id/eprint/36976/ http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf |