Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae)
Crude extracts and isolated compounds from leaves, stem bark and roots of Murraya koenigii including (1) mahanimbine, (2) girinimbine, (3) murrayacine, (4) murrayanine, (5) murrayafoline A. and (6) 3-methylcarbazole were screened for cytotoxic activity against HL-60 cancer cell lines (human T-promye...
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| Format: | Article |
| Language: | English |
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2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36954/ http://psasir.upm.edu.my/id/eprint/36954/1/Cytotoxic%20carbazole%20alkaloids%20from%20Murraya%20koenigii.pdf |
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| author | Md. Sukari, Mohd. Aspollah Ismail, N. Abu Bakar, Noor Haslizawati Ithnin, Nur Liyana |
| author_facet | Md. Sukari, Mohd. Aspollah Ismail, N. Abu Bakar, Noor Haslizawati Ithnin, Nur Liyana |
| author_sort | Md. Sukari, Mohd. Aspollah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Crude extracts and isolated compounds from leaves, stem bark and roots of Murraya koenigii including (1) mahanimbine, (2) girinimbine, (3) murrayacine, (4) murrayanine, (5) murrayafoline A. and (6) 3-methylcarbazole were screened for cytotoxic activity against HL-60 cancer cell lines (human T-promyelocytic leukemia), MCF-7 cancer cell lines (human breast cancer), HT-29 cancer cell lines (human colon cancer) and HeLa cancer cell lines (human cervical carcinoma cancer). The cytotoxic potential of the isolated compounds was determined by using MTT (3-[4,5-dimethyl-2-thiazolyl]-2-5-diphenyl-2H-tetrazolium bromide) method. Most of the tested samples showed strong activity against four cancer cell lines with IC50 value less than 30 μg/ml. |
| first_indexed | 2025-11-15T09:35:07Z |
| format | Article |
| id | upm-36954 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:35:07Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-369542015-10-21T04:38:02Z http://psasir.upm.edu.my/id/eprint/36954/ Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) Md. Sukari, Mohd. Aspollah Ismail, N. Abu Bakar, Noor Haslizawati Ithnin, Nur Liyana Crude extracts and isolated compounds from leaves, stem bark and roots of Murraya koenigii including (1) mahanimbine, (2) girinimbine, (3) murrayacine, (4) murrayanine, (5) murrayafoline A. and (6) 3-methylcarbazole were screened for cytotoxic activity against HL-60 cancer cell lines (human T-promyelocytic leukemia), MCF-7 cancer cell lines (human breast cancer), HT-29 cancer cell lines (human colon cancer) and HeLa cancer cell lines (human cervical carcinoma cancer). The cytotoxic potential of the isolated compounds was determined by using MTT (3-[4,5-dimethyl-2-thiazolyl]-2-5-diphenyl-2H-tetrazolium bromide) method. Most of the tested samples showed strong activity against four cancer cell lines with IC50 value less than 30 μg/ml. 2014-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36954/1/Cytotoxic%20carbazole%20alkaloids%20from%20Murraya%20koenigii.pdf Md. Sukari, Mohd. Aspollah and Ismail, N. and Abu Bakar, Noor Haslizawati and Ithnin, Nur Liyana (2014) Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae). Research Journal of Chemistry and Environment, 18 (11). pp. 8-11. ISSN 0972-0626; ESSN: 2278-4527 |
| spellingShingle | Md. Sukari, Mohd. Aspollah Ismail, N. Abu Bakar, Noor Haslizawati Ithnin, Nur Liyana Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title | Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title_full | Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title_fullStr | Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title_full_unstemmed | Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title_short | Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae) |
| title_sort | cytotoxic carbazole alkaloids from murraya koenigii (rutaceae) |
| url | http://psasir.upm.edu.my/id/eprint/36954/ http://psasir.upm.edu.my/id/eprint/36954/1/Cytotoxic%20carbazole%20alkaloids%20from%20Murraya%20koenigii.pdf |