Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and...
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| Format: | Article |
| Language: | English |
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Scientific Research Publishing
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36953/ http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf |
| _version_ | 1848848476714041344 |
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| author | Ahmad, Kartini Tan, Siow Ping Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Nafiah, Mohd Azlan |
| author_facet | Ahmad, Kartini Tan, Siow Ping Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Nafiah, Mohd Azlan |
| author_sort | Ahmad, Kartini |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay. |
| first_indexed | 2025-11-15T09:35:07Z |
| format | Article |
| id | upm-36953 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:35:07Z |
| publishDate | 2014 |
| publisher | Scientific Research Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-369532015-08-21T04:08:37Z http://psasir.upm.edu.my/id/eprint/36953/ Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng Ahmad, Kartini Tan, Siow Ping Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Nafiah, Mohd Azlan Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay. Scientific Research Publishing 2014-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf Ahmad, Kartini and Tan, Siow Ping and Md. Sukari, Mohd. Aspollah and Ali, Abdul Manaf and Nafiah, Mohd Azlan (2014) Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng. American Journal of Plant Sciences, 5 (19). pp. 2869-2877. ISSN 2158-2742; ESSN: 2158-2750 http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49653#.VYd3jkb8bEY 10.4236/ajps.2014.519302 |
| spellingShingle | Ahmad, Kartini Tan, Siow Ping Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Nafiah, Mohd Azlan Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title | Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title_full | Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title_fullStr | Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title_full_unstemmed | Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title_short | Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng |
| title_sort | cytotoxic and anti-tumour promoting activities of carbazole alkaloids from malayan murraya koenigii (l.) spreng |
| url | http://psasir.upm.edu.my/id/eprint/36953/ http://psasir.upm.edu.my/id/eprint/36953/ http://psasir.upm.edu.my/id/eprint/36953/ http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf |