Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanopa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36908/ http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf |
| _version_ | 1848848463618375680 |
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| author | Dorniani, Dena Kura, Aminu Umar Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| author_facet | Dorniani, Dena Kura, Aminu Umar Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| author_sort | Dorniani, Dena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs–PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG–PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet–visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs–PEG–PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes. |
| first_indexed | 2025-11-15T09:34:54Z |
| format | Article |
| id | upm-36908 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:34:54Z |
| publishDate | 2014 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-369082015-10-06T02:57:56Z http://psasir.upm.edu.my/id/eprint/36908/ Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications Dorniani, Dena Kura, Aminu Umar Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs–PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG–PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet–visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs–PEG–PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes. Springer 2014-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf Dorniani, Dena and Kura, Aminu Umar and Hussein, Mohd Zobir and Fakurazi, Sharida and Shaari, Abdul Halim and Ahmad, Zalinah (2014) Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications. Journal of Materials Science, 49 (24). pp. 8487-8497. ISSN 0022-2461; ESSN:1573-4803 10.1007/s10853-014-8559-7 |
| spellingShingle | Dorniani, Dena Kura, Aminu Umar Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title | Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title_full | Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title_fullStr | Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title_full_unstemmed | Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title_short | Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications |
| title_sort | controlled-release formulation of perindopril erbumine loaded peg-coated magnetite nanoparticles for biomedical applications |
| url | http://psasir.upm.edu.my/id/eprint/36908/ http://psasir.upm.edu.my/id/eprint/36908/ http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf |