Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus
Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36872/ http://psasir.upm.edu.my/id/eprint/36872/1/Computer%20aided%20screening%20of%20secreted%20frizzled.pdf |
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| author | Bukhari, Shazia Anwer Shamshari, Waseem Akhtar Ur-Rahman, Mahmood Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. |
| author_facet | Bukhari, Shazia Anwer Shamshari, Waseem Akhtar Ur-Rahman, Mahmood Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. |
| author_sort | Bukhari, Shazia Anwer |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels. This study was therefore designed to analyze the SFRP4 and to find its potential inhibitors. SFRP4 was analyzed by bio-informatics tools of sequence tool and structure tool. A total of three potential inhibitors of SFRP4 were found, namely cyclothiazide, clopamide and perindopril. These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide). The findings suggest the possible treatment of diabetes mellitus type 2 by inhibiting the SFRP4 using the inhibitors cyclothiazide, clopamide and perindopril. |
| first_indexed | 2025-11-15T09:34:45Z |
| format | Article |
| id | upm-36872 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:34:45Z |
| publishDate | 2014 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-368722015-08-21T03:41:26Z http://psasir.upm.edu.my/id/eprint/36872/ Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus Bukhari, Shazia Anwer Shamshari, Waseem Akhtar Ur-Rahman, Mahmood Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels. This study was therefore designed to analyze the SFRP4 and to find its potential inhibitors. SFRP4 was analyzed by bio-informatics tools of sequence tool and structure tool. A total of three potential inhibitors of SFRP4 were found, namely cyclothiazide, clopamide and perindopril. These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide). The findings suggest the possible treatment of diabetes mellitus type 2 by inhibiting the SFRP4 using the inhibitors cyclothiazide, clopamide and perindopril. MDPI AG 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36872/1/Computer%20aided%20screening%20of%20secreted%20frizzled.pdf Bukhari, Shazia Anwer and Shamshari, Waseem Akhtar and Ur-Rahman, Mahmood and Zia-Ul-Haq, Muhammad and Jaafar, Hawa Z. E. (2014) Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus. Molecules, 19 (7). pp. 10129-10136. ISSN 1420-3049 http://www.mdpi.com/1420-3049/19/7/10129 10.3390/molecules190710129 |
| spellingShingle | Bukhari, Shazia Anwer Shamshari, Waseem Akhtar Ur-Rahman, Mahmood Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title | Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title_full | Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title_fullStr | Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title_full_unstemmed | Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title_short | Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control to diabetes mellitus |
| title_sort | computer aided screening of secreted frizzled-related protein 4 (sfrp4): a potential control to diabetes mellitus |
| url | http://psasir.upm.edu.my/id/eprint/36872/ http://psasir.upm.edu.my/id/eprint/36872/ http://psasir.upm.edu.my/id/eprint/36872/ http://psasir.upm.edu.my/id/eprint/36872/1/Computer%20aided%20screening%20of%20secreted%20frizzled.pdf |