Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application
Box-Behnken (BBD) and central composite rotatable designs (CCRD) were used as statistical multivariate methods in the formulation optimization of fullerene loaded nano-emulsions. Effect of palm kernel oil ester (10-20%, w/w), emulsifier (5-10%, w/w) and xanthan gum (0.6-1.0%, w/w) as formulation var...
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| Format: | Article |
| Language: | English |
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Elsevier
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36835/ http://psasir.upm.edu.my/id/eprint/36835/1/Comparison%20of%20Box.pdf |
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| author | Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Masoumia, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia |
| author_facet | Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Masoumia, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia |
| author_sort | Ngan, Cheng Loong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Box-Behnken (BBD) and central composite rotatable designs (CCRD) were used as statistical multivariate methods in the formulation optimization of fullerene loaded nano-emulsions. Effect of palm kernel oil ester (10-20%, w/w), emulsifier (5-10%, w/w) and xanthan gum (0.6-1.0%, w/w) as formulation variables on the particle size, ζ-potential and viscosity of the nano-emulsions were investigated. Under the optimum conditions, CCRD model predicted the response values for particle size, ζ-potential and viscosity were 153.6. nm, -53.4. mV and 42.1. Pa. s, respectively. Nonetheless, BBD model suggested that the optimum conditions for a fullerene loaded nano-emulsion would gave particle size, ζ-potential and viscosity of 151.6. nm, -53.8. mV and 43.1. Pa. s, respectively. The actual response according to suggested compositions for both models showed excellent agreement with the predicted value with residual standard error (RSE) of less than 4%. Optimum nano-emulsions were stable during storage at 25 and 45. °C for 90 days and freeze-thaw cycle. |
| first_indexed | 2025-11-15T09:34:35Z |
| format | Article |
| id | upm-36835 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:34:35Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-368352015-12-03T03:30:46Z http://psasir.upm.edu.my/id/eprint/36835/ Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Masoumia, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia Box-Behnken (BBD) and central composite rotatable designs (CCRD) were used as statistical multivariate methods in the formulation optimization of fullerene loaded nano-emulsions. Effect of palm kernel oil ester (10-20%, w/w), emulsifier (5-10%, w/w) and xanthan gum (0.6-1.0%, w/w) as formulation variables on the particle size, ζ-potential and viscosity of the nano-emulsions were investigated. Under the optimum conditions, CCRD model predicted the response values for particle size, ζ-potential and viscosity were 153.6. nm, -53.4. mV and 42.1. Pa. s, respectively. Nonetheless, BBD model suggested that the optimum conditions for a fullerene loaded nano-emulsion would gave particle size, ζ-potential and viscosity of 151.6. nm, -53.8. mV and 43.1. Pa. s, respectively. The actual response according to suggested compositions for both models showed excellent agreement with the predicted value with residual standard error (RSE) of less than 4%. Optimum nano-emulsions were stable during storage at 25 and 45. °C for 90 days and freeze-thaw cycle. Elsevier 2014-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36835/1/Comparison%20of%20Box.pdf Ngan, Cheng Loong and Basri, Mahiran and Lye, Fui Fang and Masoumia, Hamid Reza Fard and Tripathy, Minaketan and Karjiban, Roghayeh Abedi and Abdul Malek, Emilia (2014) Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application. Industrial Crops and Products, 59 . pp. 309-317. ISSN 0926-6690; ESSN: 1872-633X 10.1016/j.indcrop.2014.05.042 |
| spellingShingle | Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Masoumia, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title | Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title_full | Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title_fullStr | Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title_full_unstemmed | Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title_short | Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| title_sort | comparison of box–behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application |
| url | http://psasir.upm.edu.my/id/eprint/36835/ http://psasir.upm.edu.my/id/eprint/36835/ http://psasir.upm.edu.my/id/eprint/36835/1/Comparison%20of%20Box.pdf |