Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro
Aim: Synovial fibroblast has emerged as a potential cellular target in progressive joint destruction in rheumatoid arthritis development. In this study, BDMC 33 (2,6‐bis[2,5‐dimethoxybenzylidene]cyclohexanone), a curcumin analogue with enhanced anti‐inflammatory activity has been synthesized and the...
| Main Authors: | Lee, Ka Heng, Abas, Faridah, Mohammed Alitheen, Noorjahan Banu, Shaari, Khozirah, Lajis, Nordin, Israf Ali, Daud Ahmad, Ahmad, Syahida |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/36780/ http://psasir.upm.edu.my/id/eprint/36780/1/36780.pdf |
Similar Items
A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages..
by: Lee, Ka Heng, et al.
Published: (2011)
by: Lee, Ka Heng, et al.
Published: (2011)
Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012)
by: Lee, Ka Heng
Published: (2012)
Anti-metastasis Effects and Mechanism of Action of Curcumin Analog (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene) Cyclohexanone (DMCH) on the SW620 Colorectal Cancer Cell Line
by: Che Rahim, Nurul Fattin, et al.
Published: (2025)
by: Che Rahim, Nurul Fattin, et al.
Published: (2025)
Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016)
by: Yakubu, Ndatsu, et al.
Published: (2016)
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)
by: Ka-Heng, Lee, et al.
Published: (2009)
Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
by: Paulraj, Felicia Simone, et al.
Published: (2019)
by: Paulraj, Felicia Simone, et al.
Published: (2019)
The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
by: Nursyamirah, Abd Razak, et al.
Published: (2017)
by: Nursyamirah, Abd Razak, et al.
Published: (2017)
Cytotoxic effect of 2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone (BHMC) and curcumin on human liver cancer cells, HepG2
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2019)
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2019)
The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells
by: Razak, Nursyamirah Abd, et al.
Published: (2017)
by: Razak, Nursyamirah Abd, et al.
Published: (2017)
Cytotoxicity and apoptosis effects of curcumin analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) cyclohexanone (DMCH) on human colon cancer cells HT29 and SW620 in vitro
by: Nurul Fattin, Che Rahim, et al.
Published: (2021)
by: Nurul Fattin, Che Rahim, et al.
Published: (2021)
Cytotoxicity and apoptosis effects of curcumin analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on human colon cancer cells HT29 and SW620 in vitro
by: Che Rahim, Nurul Fattin, et al.
Published: (2021)
by: Che Rahim, Nurul Fattin, et al.
Published: (2021)
Physiotherapy for rheumatoid arthritis
by: Briggs, Andrew, et al.
Published: (2017)
by: Briggs, Andrew, et al.
Published: (2017)
Pain mechanisms in rheumatoid arthritis
by: McWilliams, Daniel F., et al.
Published: (2017)
by: McWilliams, Daniel F., et al.
Published: (2017)
Development and validation of a bioanalytical method for quantification of 2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in rat plasma
by: Lee, Yu Zhao, et al.
Published: (2012)
by: Lee, Yu Zhao, et al.
Published: (2012)
Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)
by: Razali, Nurul Atika, et al.
Published: (2018)
by: Razali, Nurul Atika, et al.
Published: (2018)
Acute pain management in rheumatoid arthritis
by: Abdullah, Hilmi
Published: (2014)
by: Abdullah, Hilmi
Published: (2014)
Anemia in Malaysian women with rheumatoid arthritis
by: Hussein, Heselyn, et al.
Published: (2014)
by: Hussein, Heselyn, et al.
Published: (2014)
Novel therapeutic targets in rheumatoid arthritis
by: Sakthiswary Rajalingham,
Published: (2018)
by: Sakthiswary Rajalingham,
Published: (2018)
Pain and daily activities in rheumatoid arthritis
by: Ahlstrand, I., et al.
Published: (2012)
by: Ahlstrand, I., et al.
Published: (2012)
Management of pregnancy in women with rheumatoid arthritis
by: Ngian, G., et al.
Published: (2016)
by: Ngian, G., et al.
Published: (2016)
Toxicity effects of curcumin analogue, 2, 6-BIS (2-fluorobenzylidene) cyclohexanone on zebrafish (Danio rerio F. Hamilton, 1822)
by: Nazarudin, Nur Amiza
Published: (2017)
by: Nazarudin, Nur Amiza
Published: (2017)
Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.
by: Lee, Ming Tatt, et al.
Published: (2012)
by: Lee, Ming Tatt, et al.
Published: (2012)
Discordance between pain and inflammation in rheumatoid arthritis
by: McWilliams, Daniel F.
Published: (2018)
by: McWilliams, Daniel F.
Published: (2018)
Correlates of Fatigue in People Living with Rheumatoid Arthritis
by: van Zanten, J., et al.
Published: (2016)
by: van Zanten, J., et al.
Published: (2016)
Gender differences in clinical characteristics of rheumatoid arthritis
by: Sakthiswary R,, et al.
Published: (2023)
by: Sakthiswary R,, et al.
Published: (2023)
The clinical utility of accelerometry in patients with rheumatoid arthritis
by: Prioreschi, A., et al.
Published: (2013)
by: Prioreschi, A., et al.
Published: (2013)
Pathogenic advances in rheumatoid arthritis: a review
by: Abdullah, Muhammad Nazrul Hakim, et al.
Published: (2024)
by: Abdullah, Muhammad Nazrul Hakim, et al.
Published: (2024)
The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.
by: Chau, Ling Tham, et al.
Published: (2011)
by: Chau, Ling Tham, et al.
Published: (2011)
Evaluating joint protection education for people with rheumatoid arthritis
by: Hammond, Alison
Published: (1994)
by: Hammond, Alison
Published: (1994)
Erosive and osteoarthritic structural progression in early rheumatoid arthritis
by: McWilliams, Daniel F., et al.
Published: (2016)
by: McWilliams, Daniel F., et al.
Published: (2016)
Outcomes of Percutaneous Coronary Intervention in Patients With Rheumatoid Arthritis
by: Dawson, L.P., et al.
Published: (2021)
by: Dawson, L.P., et al.
Published: (2021)
Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.
by: Guo, Q., et al.
Published: (2018)
by: Guo, Q., et al.
Published: (2018)
Difficulty in eye drop administration for people with rheumatoid arthritis
by: Adamson, E., et al.
Published: (2016)
by: Adamson, E., et al.
Published: (2016)
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
by: Liew, Kong Yen, et al.
Published: (2024)
by: Liew, Kong Yen, et al.
Published: (2024)
Correlation of rheumatoid factor serotypes and computed tomography findings in rheumatoid arthritis related interstitial lung disease
by: Sakthiswary Rajalingham,, et al.
Published: (2019)
by: Sakthiswary Rajalingham,, et al.
Published: (2019)
Sexual dysfunction and its determinants in Malaysian women with rheumatoid arthritis
by: Shahar, Mohammad Arif, et al.
Published: (2012)
by: Shahar, Mohammad Arif, et al.
Published: (2012)
Closing the pregnancy-related information gap for women with rheumatoid arthritis
by: Ackerman, I., et al.
Published: (2016)
by: Ackerman, I., et al.
Published: (2016)
Safety of anti-rheumatic drugs for rheumatoid arthritis in pregnancy and lactation
by: Ngian, G., et al.
Published: (2016)
by: Ngian, G., et al.
Published: (2016)
Living in the present: Women’s everyday experiences of living with rheumatoid arthritis
by: Barns, Angela, et al.
Published: (2015)
by: Barns, Angela, et al.
Published: (2015)
Respiratory involvement in rheumatoid arthritis physiologic abnormalities and determinants of radiographic
by: Mohamed Ismail, Asmahan
Published: (2002)
by: Mohamed Ismail, Asmahan
Published: (2002)
Similar Items
-
A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages..
by: Lee, Ka Heng, et al.
Published: (2011) -
Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012) -
Anti-metastasis Effects and Mechanism of Action of Curcumin Analog (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene) Cyclohexanone (DMCH) on the SW620 Colorectal Cancer Cell Line
by: Che Rahim, Nurul Fattin, et al.
Published: (2025) -
Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016) -
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)