Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus
The ability of a heat-inactivated whole virus from a highly virulent infectious bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli provided protection against a hvIBDV challenge in specific-pathogen-free (SPF) chickens. Six out of seven chickens that were injected three t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Veterinary Science
2006
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/36728/ http://psasir.upm.edu.my/id/eprint/36728/1/Efficacy%20of%20VP2%20protein%20expressed%20in%20E.%20coli%20for%20protection%20against%20highly%20virulent%20infectious%20bursal%20disease%20virus.pdf |
| _version_ | 1848848413904338944 |
|---|---|
| author | Omar, Abdul Rahman Chong, Lee Kim Bejo, Mohd Hair Ideris, Aini |
| author_facet | Omar, Abdul Rahman Chong, Lee Kim Bejo, Mohd Hair Ideris, Aini |
| author_sort | Omar, Abdul Rahman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The ability of a heat-inactivated whole virus from a highly virulent infectious bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli provided protection against a hvIBDV challenge in specific-pathogen-free (SPF) chickens. Six out of seven chickens that were injected three times with crude VP2 protein developed significant antibody titer against IBDV. However, only four out of the seven chickens survived the hvIBDV challenge. Despite showing low antibody titer profiles, all chickens immunized with the heat-inactivated whole virus also survived the challenged with hvIBDV. However, all of these chickens had bursal atrophy and mild to moderate depletion of lymphocytes. Thus, antibodies raised against IBDV VP2 protein expressed in E. coli and denatured IBDV proteins induced some degree of protection against mortality but not against bursal damage following challenge with hvIBDV. |
| first_indexed | 2025-11-15T09:34:07Z |
| format | Article |
| id | upm-36728 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:34:07Z |
| publishDate | 2006 |
| publisher | The Korean Society of Veterinary Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-367282020-07-06T03:13:52Z http://psasir.upm.edu.my/id/eprint/36728/ Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus Omar, Abdul Rahman Chong, Lee Kim Bejo, Mohd Hair Ideris, Aini The ability of a heat-inactivated whole virus from a highly virulent infectious bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli provided protection against a hvIBDV challenge in specific-pathogen-free (SPF) chickens. Six out of seven chickens that were injected three times with crude VP2 protein developed significant antibody titer against IBDV. However, only four out of the seven chickens survived the hvIBDV challenge. Despite showing low antibody titer profiles, all chickens immunized with the heat-inactivated whole virus also survived the challenged with hvIBDV. However, all of these chickens had bursal atrophy and mild to moderate depletion of lymphocytes. Thus, antibodies raised against IBDV VP2 protein expressed in E. coli and denatured IBDV proteins induced some degree of protection against mortality but not against bursal damage following challenge with hvIBDV. The Korean Society of Veterinary Science 2006 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/36728/1/Efficacy%20of%20VP2%20protein%20expressed%20in%20E.%20coli%20for%20protection%20against%20highly%20virulent%20infectious%20bursal%20disease%20virus.pdf Omar, Abdul Rahman and Chong, Lee Kim and Bejo, Mohd Hair and Ideris, Aini (2006) Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus. Journal of Veterinary Science, 7 (3). pp. 241-247. ISSN 1229-845X; ESSN: 1976-555X https://vetsci.org/search.php?where=aview&id=10.4142/jvs.2006.7.3.241&code=0118JVS&vmode=AONLY 10.4142/jvs.2006.7.3.241 |
| spellingShingle | Omar, Abdul Rahman Chong, Lee Kim Bejo, Mohd Hair Ideris, Aini Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title | Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title_full | Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title_fullStr | Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title_full_unstemmed | Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title_short | Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus |
| title_sort | efficacy of vp2 protein expressed in e. coli for protection against highly virulent infectious bursal disease virus |
| url | http://psasir.upm.edu.my/id/eprint/36728/ http://psasir.upm.edu.my/id/eprint/36728/ http://psasir.upm.edu.my/id/eprint/36728/ http://psasir.upm.edu.my/id/eprint/36728/1/Efficacy%20of%20VP2%20protein%20expressed%20in%20E.%20coli%20for%20protection%20against%20highly%20virulent%20infectious%20bursal%20disease%20virus.pdf |