Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation

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Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation

Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although...

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Bibliographic Details
Main Authors:	Abd Aziz, Noraini, Stanbridge, Eric J., Shafee, Norazizah
Format:	Article
Language:	English
Published:	Spandidos Publications 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/36675/ http://psasir.upm.edu.my/id/eprint/36675/1/Bortezomib%20attenuates%20HIF-1-%20but%20not%20HIF-2-mediated%20transcriptional%20activation.pdf

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