Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme
The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectiv...
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| Format: | Article |
| Language: | English |
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Elsevier
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36590/ http://psasir.upm.edu.my/id/eprint/36590/1/Asymmetric%20aldol%20reactions%20catalyzed%20by%20the%20promiscuous%20aldo.pdf |
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| author | Bayat, Saadi Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Tejo, Bimo Ario Abdul Rahman, Mohd Basyaruddin |
| author_facet | Bayat, Saadi Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Tejo, Bimo Ario Abdul Rahman, Mohd Basyaruddin |
| author_sort | Bayat, Saadi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed. |
| first_indexed | 2025-11-15T09:33:30Z |
| format | Article |
| id | upm-36590 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:33:30Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-365902015-08-20T08:07:13Z http://psasir.upm.edu.my/id/eprint/36590/ Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme Bayat, Saadi Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Tejo, Bimo Ario Abdul Rahman, Mohd Basyaruddin The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed. Elsevier 2014-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36590/1/Asymmetric%20aldol%20reactions%20catalyzed%20by%20the%20promiscuous%20aldo.pdf Bayat, Saadi and Abd. Malek, Emilia and Mohd Yahaya, Normi and Salleh, Abu Bakar and Tejo, Bimo Ario and Abdul Rahman, Mohd Basyaruddin (2014) Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme. Tetrahedron Letters, 55 (46). pp. 6303-6306. ISSN 0040-4039; ESSN: 1873-3581 10.1016/j.tetlet.2014.09.012 |
| spellingShingle | Bayat, Saadi Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Tejo, Bimo Ario Abdul Rahman, Mohd Basyaruddin Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title | Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title_full | Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title_fullStr | Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title_full_unstemmed | Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title_short | Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| title_sort | asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme |
| url | http://psasir.upm.edu.my/id/eprint/36590/ http://psasir.upm.edu.my/id/eprint/36590/ http://psasir.upm.edu.my/id/eprint/36590/1/Asymmetric%20aldol%20reactions%20catalyzed%20by%20the%20promiscuous%20aldo.pdf |