Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites
The treatment of tuberculosis by chemotherapy is complicated due to multiple drug prescriptions, long treatment duration, and adverse side effects. We report here for the first time an in vitro therapeutic effect of nanocomposites based on para-aminosalicylic acid with zinc layered hydroxide (PAS-ZL...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36486/ http://psasir.upm.edu.my/id/eprint/36486/1/Antimycobacterial.pdf |
| _version_ | 1848848346002751488 |
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| author | Saifullah, Bullo El Zowalaty, Mohamed Ezzat Arulselvan, Palanisamy Fakurazi, Sharida Webster, Thomas Jay Geilich, Benjamin M. Hussein, Mohd Zobir |
| author_facet | Saifullah, Bullo El Zowalaty, Mohamed Ezzat Arulselvan, Palanisamy Fakurazi, Sharida Webster, Thomas Jay Geilich, Benjamin M. Hussein, Mohd Zobir |
| author_sort | Saifullah, Bullo |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The treatment of tuberculosis by chemotherapy is complicated due to multiple drug prescriptions, long treatment duration, and adverse side effects. We report here for the first time an in vitro therapeutic effect of nanocomposites based on para-aminosalicylic acid with zinc layered hydroxide (PAS-ZLH) and zinc-aluminum layered double hydroxides (PAS-Zn/Al LDH), against mycobacteria, Gram-positive bacteria, and Gram-negative bacteria. The nanocomposites demonstrated good antimycobacterial activity and were found to be effective in killing Gram-positive and Gram-negative bacteria. A biocompatibility study revealed good biocompatibility of the PAS-ZLH nanocomposites against normal human MRC-5 lung cells. The para-aminosalicylic acid loading was quantified with high-performance liquid chromatography analysis. In summary, the present preliminary in vitro studies are highly encouraging for further in vivo studies of PAS-ZLH and PAS-Zn/Al LDH nanocomposites to treat tuberculosis. |
| first_indexed | 2025-11-15T09:33:02Z |
| format | Article |
| id | upm-36486 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:33:02Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-364862016-01-26T01:40:12Z http://psasir.upm.edu.my/id/eprint/36486/ Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites Saifullah, Bullo El Zowalaty, Mohamed Ezzat Arulselvan, Palanisamy Fakurazi, Sharida Webster, Thomas Jay Geilich, Benjamin M. Hussein, Mohd Zobir The treatment of tuberculosis by chemotherapy is complicated due to multiple drug prescriptions, long treatment duration, and adverse side effects. We report here for the first time an in vitro therapeutic effect of nanocomposites based on para-aminosalicylic acid with zinc layered hydroxide (PAS-ZLH) and zinc-aluminum layered double hydroxides (PAS-Zn/Al LDH), against mycobacteria, Gram-positive bacteria, and Gram-negative bacteria. The nanocomposites demonstrated good antimycobacterial activity and were found to be effective in killing Gram-positive and Gram-negative bacteria. A biocompatibility study revealed good biocompatibility of the PAS-ZLH nanocomposites against normal human MRC-5 lung cells. The para-aminosalicylic acid loading was quantified with high-performance liquid chromatography analysis. In summary, the present preliminary in vitro studies are highly encouraging for further in vivo studies of PAS-ZLH and PAS-Zn/Al LDH nanocomposites to treat tuberculosis. Dove Medical Press 2014-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36486/1/Antimycobacterial.pdf Saifullah, Bullo and El Zowalaty, Mohamed Ezzat and Arulselvan, Palanisamy and Fakurazi, Sharida and Webster, Thomas Jay and Geilich, Benjamin M. and Hussein, Mohd Zobir (2014) Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites. Drug Design, Development and Therapy, 8. 1029-1036 . ISSN 1177-8881 http://www.dovepress.com/antimycobacterial-antimicrobial-and-biocompatibility-properties-of-par-peer-reviewed-article-DDDT 10.2147/DDDT.S63753 |
| spellingShingle | Saifullah, Bullo El Zowalaty, Mohamed Ezzat Arulselvan, Palanisamy Fakurazi, Sharida Webster, Thomas Jay Geilich, Benjamin M. Hussein, Mohd Zobir Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title | Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title_full | Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title_fullStr | Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title_full_unstemmed | Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title_short | Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites |
| title_sort | antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and zn/al layered double hydroxide nanocomposites |
| url | http://psasir.upm.edu.my/id/eprint/36486/ http://psasir.upm.edu.my/id/eprint/36486/ http://psasir.upm.edu.my/id/eprint/36486/ http://psasir.upm.edu.my/id/eprint/36486/1/Antimycobacterial.pdf |