Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species
Human plasma inhibits arachidonic acid metabolism and platelet aggregation. This helps human form a haemostatic control system that prevents the progress of certain aggregatory or inflammatory reactions. Whether this property of plasma is unique to human or extends to other species is not well known...
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| Format: | Article |
| Language: | English |
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MDPI
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36477/ http://psasir.upm.edu.my/id/eprint/36477/1/Anti2.pdf |
| _version_ | 1848848343427448832 |
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| author | Ahmed, Sagheer Gul, Saima Idris, Fazean Hussain, Abrar Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Moga, Marius |
| author_facet | Ahmed, Sagheer Gul, Saima Idris, Fazean Hussain, Abrar Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Moga, Marius |
| author_sort | Ahmed, Sagheer |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Human plasma inhibits arachidonic acid metabolism and platelet aggregation. This helps human form a haemostatic control system that prevents the progress of certain aggregatory or inflammatory reactions. Whether this property of plasma is unique to human or extends to other species is not well known. It is speculated that this protective ability of plasma remains evolutionarily conserved in different mammals. In order to confirm this, the effect of plasma from 12 different mammalian species was investigated for its inhibitory potential against arachidonic acid metabolism and platelet aggregation. Metabolism of arachidonic acid by cyclooxygenase and lipoxygenase pathways was studies using radio-immuno assay and thin layer chromatography while platelet aggregation in the plasma of various mammals was monitored following turbedmetric method in a dual channel aggregometer. Results indicate that inhibition of AA metabolism and platelet aggregation is a common feature of plasma obtained from different mammalian species, although there exists large interspecies variation. This shows that besides human, other mammals also possess general protective mechanisms against various aggregatory and inflammatory conditions and this anti-inflammatory property of the plasma is evolutionarily conserved in mammalian species. The most likely candidates responsible for these properties of plasma include haptoglobin, albumin and lipoproteins. |
| first_indexed | 2025-11-15T09:33:00Z |
| format | Article |
| id | upm-36477 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:33:00Z |
| publishDate | 2014 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-364772015-08-25T08:31:00Z http://psasir.upm.edu.my/id/eprint/36477/ Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species Ahmed, Sagheer Gul, Saima Idris, Fazean Hussain, Abrar Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Moga, Marius Human plasma inhibits arachidonic acid metabolism and platelet aggregation. This helps human form a haemostatic control system that prevents the progress of certain aggregatory or inflammatory reactions. Whether this property of plasma is unique to human or extends to other species is not well known. It is speculated that this protective ability of plasma remains evolutionarily conserved in different mammals. In order to confirm this, the effect of plasma from 12 different mammalian species was investigated for its inhibitory potential against arachidonic acid metabolism and platelet aggregation. Metabolism of arachidonic acid by cyclooxygenase and lipoxygenase pathways was studies using radio-immuno assay and thin layer chromatography while platelet aggregation in the plasma of various mammals was monitored following turbedmetric method in a dual channel aggregometer. Results indicate that inhibition of AA metabolism and platelet aggregation is a common feature of plasma obtained from different mammalian species, although there exists large interspecies variation. This shows that besides human, other mammals also possess general protective mechanisms against various aggregatory and inflammatory conditions and this anti-inflammatory property of the plasma is evolutionarily conserved in mammalian species. The most likely candidates responsible for these properties of plasma include haptoglobin, albumin and lipoproteins. MDPI 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36477/1/Anti2.pdf Ahmed, Sagheer and Gul, Saima and Idris, Fazean and Hussain, Abrar and Zia-Ul-Haq, Muhammad and Jaafar, Hawa Z. E. and Moga, Marius (2014) Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species. Molecules, 19 (8). pp. 11385-11394. ISSN 1431-5157; ESSN: 1420-3049 http://www.mdpi.com/1420-3049/19/8/11385 10.3390/molecules190811385 |
| spellingShingle | Ahmed, Sagheer Gul, Saima Idris, Fazean Hussain, Abrar Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Moga, Marius Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title | Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title_full | Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title_fullStr | Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title_full_unstemmed | Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title_short | Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| title_sort | anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species |
| url | http://psasir.upm.edu.my/id/eprint/36477/ http://psasir.upm.edu.my/id/eprint/36477/ http://psasir.upm.edu.my/id/eprint/36477/ http://psasir.upm.edu.my/id/eprint/36477/1/Anti2.pdf |