Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid
Background: We characterize a novel nanocomposite that acts as an efficient anticancer agent. Methods: This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36470/ http://psasir.upm.edu.my/id/eprint/36470/1/Anticancer%20nanodelivery%20system%20with%20controlled%20release%20property%20based%20on%20protocatechuate.pdf |
| _version_ | 1848848341514846208 |
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| author | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain |
| author_facet | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain |
| author_sort | Barahuie, Farahnaz |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: We characterize a novel nanocomposite that acts as an efficient anticancer agent. Methods: This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors. Results: The resulting protocatechuic acid nanocomposite (PAN) showed a basal spacing of 12.7 Å, indicating that protocatechuate was intercalated in a monolayer arrangement, with an angle of 54° from the Z-axis between the interlayers of the zinc layered hydroxide, and an estimated drug loading of about 35.7%. PAN exhibited the properties of a mesoporous type material, with greatly enhanced thermal stability of protocatechuate as compared to its free counterpart. The presence of protocatechuate in the interlayers of the zinc layered hydroxide was further supported by Fourier transform infrared spectroscopy. Protocatechuate was released from PAN in a slow and sustained manner. This mechanism of release was well represented by a pseudo-second order kinetics model. PAN has shown increased cytotoxicity compared to the free form of protocatechuic acid in all cancer cell lines tested. Tumor growth suppression was extensive, particularly in HepG2 and HT29 cell lines. Conclusion: PAN is suitable for use as a controlled release formulation, and our in vitro evidence indicates that PAN is an effective anticancer agent. PAN may have potential as a chemotherapeutic drug for human cancer. |
| first_indexed | 2025-11-15T09:32:58Z |
| format | Article |
| id | upm-36470 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:32:58Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-364702015-08-20T08:20:12Z http://psasir.upm.edu.my/id/eprint/36470/ Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain Background: We characterize a novel nanocomposite that acts as an efficient anticancer agent. Methods: This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors. Results: The resulting protocatechuic acid nanocomposite (PAN) showed a basal spacing of 12.7 Å, indicating that protocatechuate was intercalated in a monolayer arrangement, with an angle of 54° from the Z-axis between the interlayers of the zinc layered hydroxide, and an estimated drug loading of about 35.7%. PAN exhibited the properties of a mesoporous type material, with greatly enhanced thermal stability of protocatechuate as compared to its free counterpart. The presence of protocatechuate in the interlayers of the zinc layered hydroxide was further supported by Fourier transform infrared spectroscopy. Protocatechuate was released from PAN in a slow and sustained manner. This mechanism of release was well represented by a pseudo-second order kinetics model. PAN has shown increased cytotoxicity compared to the free form of protocatechuic acid in all cancer cell lines tested. Tumor growth suppression was extensive, particularly in HepG2 and HT29 cell lines. Conclusion: PAN is suitable for use as a controlled release formulation, and our in vitro evidence indicates that PAN is an effective anticancer agent. PAN may have potential as a chemotherapeutic drug for human cancer. Dove Medical Press 2014-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36470/1/Anticancer%20nanodelivery%20system%20with%20controlled%20release%20property%20based%20on%20protocatechuate.pdf Barahuie, Farahnaz and Hussein, Mohd Zobir and Abd Gani, Shafinaz and Fakurazi, Sharida and Zainal, Zulkarnain (2014) Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid. International Journal of Nanomedicine, 9 (1). pp. 3137-3149. ISSN 1176-9114; ESSN: 1178-2013 http://www.dovepress.com/anticancer-nanodelivery-system-with-controlled-release-property-based--peer-reviewed-article-IJN 10.2147/IJN.S59541 |
| spellingShingle | Barahuie, Farahnaz Hussein, Mohd Zobir Abd Gani, Shafinaz Fakurazi, Sharida Zainal, Zulkarnain Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title | Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title_full | Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title_fullStr | Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title_full_unstemmed | Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title_short | Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| title_sort | anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid |
| url | http://psasir.upm.edu.my/id/eprint/36470/ http://psasir.upm.edu.my/id/eprint/36470/ http://psasir.upm.edu.my/id/eprint/36470/ http://psasir.upm.edu.my/id/eprint/36470/1/Anticancer%20nanodelivery%20system%20with%20controlled%20release%20property%20based%20on%20protocatechuate.pdf |