A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis
Aims and Background: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are recognized as osmotic demyelination syndrome (ODS). ODS is pathologically characterized by non-inflammatory demyelination of several brain structures with sparing of axons. This condition is usually assoc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciencedomain International
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36246/ http://psasir.upm.edu.my/id/eprint/36246/1/A%20rare%20case%20of%20acute%20psychosis%20as%20an%20isolated%20manifestation%20of%20extrapontine%20myelinolysis.pdf |
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| author | Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Basri, Hamidon Hasan, Shariful Mohd Sazlly Lim, Sazlyna Foo, Yoke Loong Ching, Siew Mooi Vasudevan, Ramachandran Mohamed, Mohd Hazmi Hashim, Hasnur Zaman |
| author_facet | Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Basri, Hamidon Hasan, Shariful Mohd Sazlly Lim, Sazlyna Foo, Yoke Loong Ching, Siew Mooi Vasudevan, Ramachandran Mohamed, Mohd Hazmi Hashim, Hasnur Zaman |
| author_sort | Wan Sulaiman, Wan Aliaa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Aims and Background: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are recognized as osmotic demyelination syndrome (ODS). ODS is pathologically characterized by non-inflammatory demyelination of several brain structures with sparing of axons. This condition is usually associated with overzealous correction of hyponatraemia. Acute psychosis as the sole clinical manifestation is extremely rare. Presentation of Case: Hence, we report an interesting case of a middle-aged man who was diagnosed with EPM, following rapid correction of hyponatraemia and subsequently developed acute psychosis. He made a good recovery with supportive treatment alone. Discussion and Conclusion: The possibility of psychosis as a manifestation of ODS, particularly in patients with recent correction of hyponatraemia. The rate of correction of plasma sodium level is the key point for preventing ODS and its complications. |
| first_indexed | 2025-11-15T09:31:58Z |
| format | Article |
| id | upm-36246 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:31:58Z |
| publishDate | 2014 |
| publisher | Sciencedomain International |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-362462015-10-09T00:43:16Z http://psasir.upm.edu.my/id/eprint/36246/ A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Basri, Hamidon Hasan, Shariful Mohd Sazlly Lim, Sazlyna Foo, Yoke Loong Ching, Siew Mooi Vasudevan, Ramachandran Mohamed, Mohd Hazmi Hashim, Hasnur Zaman Aims and Background: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are recognized as osmotic demyelination syndrome (ODS). ODS is pathologically characterized by non-inflammatory demyelination of several brain structures with sparing of axons. This condition is usually associated with overzealous correction of hyponatraemia. Acute psychosis as the sole clinical manifestation is extremely rare. Presentation of Case: Hence, we report an interesting case of a middle-aged man who was diagnosed with EPM, following rapid correction of hyponatraemia and subsequently developed acute psychosis. He made a good recovery with supportive treatment alone. Discussion and Conclusion: The possibility of psychosis as a manifestation of ODS, particularly in patients with recent correction of hyponatraemia. The rate of correction of plasma sodium level is the key point for preventing ODS and its complications. Sciencedomain International 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36246/1/A%20rare%20case%20of%20acute%20psychosis%20as%20an%20isolated%20manifestation%20of%20extrapontine%20myelinolysis.pdf Wan Sulaiman, Wan Aliaa and Hoo, Fan Kee and Basri, Hamidon and Hasan, Shariful and Mohd Sazlly Lim, Sazlyna and Foo, Yoke Loong and Ching, Siew Mooi and Vasudevan, Ramachandran and Mohamed, Mohd Hazmi and Hashim, Hasnur Zaman (2014) A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis. British Journal of Medicine and Medical Research, 4 (18). pp. 3554-3560. ISSN 2231-0614 http://www.sciencedomain.org/abstract.php?iid=480&id=12&aid=4294 10.9734/BJMMR/2014/9615 |
| spellingShingle | Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Basri, Hamidon Hasan, Shariful Mohd Sazlly Lim, Sazlyna Foo, Yoke Loong Ching, Siew Mooi Vasudevan, Ramachandran Mohamed, Mohd Hazmi Hashim, Hasnur Zaman A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title | A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title_full | A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title_fullStr | A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title_full_unstemmed | A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title_short | A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| title_sort | rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis |
| url | http://psasir.upm.edu.my/id/eprint/36246/ http://psasir.upm.edu.my/id/eprint/36246/ http://psasir.upm.edu.my/id/eprint/36246/ http://psasir.upm.edu.my/id/eprint/36246/1/A%20rare%20case%20of%20acute%20psychosis%20as%20an%20isolated%20manifestation%20of%20extrapontine%20myelinolysis.pdf |