A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays
Background: The Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. The sub-ethnic groups can be divided based on the region they inhabit; the northern (Melayu Kedah and Melayu Kelantan), western (Melayu Minang)...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36165/ http://psasir.upm.edu.my/id/eprint/36165/1/36165.pdf |
| _version_ | 1848848256204800000 |
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| author | Wan Isa, Hatin Ab Rajab, Nur Shafawati Etemad, Ali Jin, Wenfei Qin, Pengfei Xu, Shuhua Jin, Li Tan, Soon Guan Limprasert, Pornprot Feisal, Merican Amir Idid, Mohammed Rizman Alwi, Zilfalil The HUGO Pan-Asian SNP Consortium, |
| author_facet | Wan Isa, Hatin Ab Rajab, Nur Shafawati Etemad, Ali Jin, Wenfei Qin, Pengfei Xu, Shuhua Jin, Li Tan, Soon Guan Limprasert, Pornprot Feisal, Merican Amir Idid, Mohammed Rizman Alwi, Zilfalil The HUGO Pan-Asian SNP Consortium, |
| author_sort | Wan Isa, Hatin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: The Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. The sub-ethnic groups can be divided based on the region they inhabit; the northern (Melayu Kedah and Melayu Kelantan), western (Melayu Minang) and southern parts (Melayu Bugis and Melayu Jawa) of Peninsular Malaysia. We analyzed 54,794 autosomal single nucleotide polymorphisms (SNPs) which were shared by 472 unrelated individuals from 17 populations to determine the genetic structure and distributions of the ancestral genetic components in five Malay sub-ethnic groups namely Melayu Bugis, Melayu Jawa, Melayu Minang, Melayu Kedah, and Melayu Kelantan. We also have included in the analysis 12 other study populations from Thailand, Indonesia, China, India, Africa and Orang Asli sub-groups in Malay Peninsula, obtained from the Pan Asian SNP Initiative (PASNPI) Consortium and International HapMap project database. Results: We found evidence of genetic influx from Indians to Malays, more in Melayu Kedah and Melayu Kelantan which are genetically different from the other Malay sub-ethnic groups, but similar to Thai Pattani. More than 98% of these northern Malays haplotypes could be found in either Indians or Chinese populations, indicating a highly admixture pattern among populations. Nevertheless, the ancestry lines of Malays, Indonesians and Thais were traced back to have shared a common ancestor with the Proto-Malays and Chinese. Conclusions: These results support genetic admixtures in the Peninsular Malaysia Malay populations and provided valuable information on the enigmatic demographical history as well as shed some insights into the origins of the Malays in the Malay Peninsula. |
| first_indexed | 2025-11-15T09:31:36Z |
| format | Article |
| id | upm-36165 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:31:36Z |
| publishDate | 2014 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-361652015-12-18T05:29:39Z http://psasir.upm.edu.my/id/eprint/36165/ A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays Wan Isa, Hatin Ab Rajab, Nur Shafawati Etemad, Ali Jin, Wenfei Qin, Pengfei Xu, Shuhua Jin, Li Tan, Soon Guan Limprasert, Pornprot Feisal, Merican Amir Idid, Mohammed Rizman Alwi, Zilfalil The HUGO Pan-Asian SNP Consortium, Background: The Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. The sub-ethnic groups can be divided based on the region they inhabit; the northern (Melayu Kedah and Melayu Kelantan), western (Melayu Minang) and southern parts (Melayu Bugis and Melayu Jawa) of Peninsular Malaysia. We analyzed 54,794 autosomal single nucleotide polymorphisms (SNPs) which were shared by 472 unrelated individuals from 17 populations to determine the genetic structure and distributions of the ancestral genetic components in five Malay sub-ethnic groups namely Melayu Bugis, Melayu Jawa, Melayu Minang, Melayu Kedah, and Melayu Kelantan. We also have included in the analysis 12 other study populations from Thailand, Indonesia, China, India, Africa and Orang Asli sub-groups in Malay Peninsula, obtained from the Pan Asian SNP Initiative (PASNPI) Consortium and International HapMap project database. Results: We found evidence of genetic influx from Indians to Malays, more in Melayu Kedah and Melayu Kelantan which are genetically different from the other Malay sub-ethnic groups, but similar to Thai Pattani. More than 98% of these northern Malays haplotypes could be found in either Indians or Chinese populations, indicating a highly admixture pattern among populations. Nevertheless, the ancestry lines of Malays, Indonesians and Thais were traced back to have shared a common ancestor with the Proto-Malays and Chinese. Conclusions: These results support genetic admixtures in the Peninsular Malaysia Malay populations and provided valuable information on the enigmatic demographical history as well as shed some insights into the origins of the Malays in the Malay Peninsula. Springer 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36165/1/36165.pdf Wan Isa, Hatin and Ab Rajab, Nur Shafawati and Etemad, Ali and Jin, Wenfei and Qin, Pengfei and Xu, Shuhua and Jin, Li and Tan, Soon Guan and Limprasert, Pornprot and Feisal, Merican Amir and Idid, Mohammed Rizman and Alwi, Zilfalil and The HUGO Pan-Asian SNP Consortium, (2014) A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays. The HUGO Journal, 8. art. no. 5. pp. 1-18. ISSN 1877-6558; ESSN: 1877-6566 http://www.thehugojournal.com/content/8/1/5/abstract 10.1186/s11568-014-0005-z |
| spellingShingle | Wan Isa, Hatin Ab Rajab, Nur Shafawati Etemad, Ali Jin, Wenfei Qin, Pengfei Xu, Shuhua Jin, Li Tan, Soon Guan Limprasert, Pornprot Feisal, Merican Amir Idid, Mohammed Rizman Alwi, Zilfalil The HUGO Pan-Asian SNP Consortium, A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title | A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title_full | A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title_fullStr | A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title_full_unstemmed | A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title_short | A genome wide pattern of population structure and admixture in Peninsular Malaysia Malays |
| title_sort | genome wide pattern of population structure and admixture in peninsular malaysia malays |
| url | http://psasir.upm.edu.my/id/eprint/36165/ http://psasir.upm.edu.my/id/eprint/36165/ http://psasir.upm.edu.my/id/eprint/36165/ http://psasir.upm.edu.my/id/eprint/36165/1/36165.pdf |