Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line

QR Code

Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line

This investigation evaluated the antileukemia properties of a zerumbone (ZER)-loaded nanostructured lipid carrier (NLC) prepared by hot high-pressure homogenization techniques in an acute human lymphoblastic leukemia (Jurkat) cell line in vitro. The apoptogenic effect of the ZER-NLC on Jurkat cells...

Full description

Bibliographic Details
Main Authors:	Rahman, Heshu Sulaiman, Abdullah, Rasedee, Abdul, Ahmad Bustamam, Allaudin, Zeenathul Nazariah, Othman, Hemn Hassan, Yeap, Swee Keong, How, Chee Wun, Wan Abd Ghani, Wan Nor Hafiza
Format:	Article
Language:	English
Published:	Dove Medical Press 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/36045/ http://psasir.upm.edu.my/id/eprint/36045/1/36045.pdf

Similar Items

Zerumbone induces apoptosis in human acute leukemia Jurkat T-cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Zerumbone induces apoptosis in Jurkat T-cell line via activation of caspase 3 and caspase 9
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model
by: Rahman, Heshu Sulaiman, et al.
Published: (2015)

Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
by: Abdul Samad, Nozlena, et al.
Published: (2014)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
by: Rahman, Heshu Sulaiman, et al.
Published: (2013)

Increased regulatory T cells in acute lymphoblastic leukemia patients
by: Idris, Siti Zuleha, et al.
Published: (2015)

Zerumbone-loaded nanostructured lipid carrier induces apoptosis of canine mammary Adenocarcinoma cells
by: Foong, Jia Ning, et al.
Published: (2018)

Apoptosis pathways induced by recombinant adenovirus in cancer cells
by: Koh, Choo Yan, et al.
Published: (2010)

A composition for treating leukemia
by: Abdullah, Rasedee, et al.
Published: (2013)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Apoptosis induction in human leukemia cell lines by gold nanoparticles synthesized using the green biosynthetic approach
by: Namvar, Farideh, et al.
Published: (2015)

Induction of apoptosis by newcastle disease virus strains AF220 and V4-UPM in human promyelocytic leukemia (HL60) and human T- lymphoblastic leukemia (CEM -SS) Cells

Induction of Apoptosis by Newcastle Disease Virus Strains AF220 and V4-UPM in Human Promyelocytic Leukemia (HL60) and Human T- Lymphoblastic Leukemia (CEM -SS) Cells

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.
by: Matthijssens, Filip, et al.
Published: (2021)

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution
by: Anderson, D., et al.
Published: (2020)

Anticancer potential of Damnacanthal and Nordamnacanthal from Morinda elliptica roots on T-lymphoblastic leukemia cells
by: Saiful Yazan, Latifah, et al.
Published: (2021)

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
by: Syam, Suvitha, et al.
Published: (2014)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Kenaf seed oil from supercritical carbon dioxide fluid extraction induced G1 phase cell cycle arrest and apoptosis in leukemia cells
by: Foo, Jhi Biau, et al.
Published: (2011)

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway
by: Waziri, Peter M., et al.
Published: (2016)

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.
by: Roels, Juliette, et al.
Published: (2020)

Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo
by: Mohan, Syam, et al.
Published: (2010)

Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin

Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2007)

Zerumbone nanoparticle preparation and characterization
by: Rahman, Heshu, et al.
Published: (2015)

Pereskia bleo leaves extract induces cell death via cell cycle arrest and apoptosis in cervical cancer cells hela
by: Salleh, Siti Farhanah Mohd, et al.
Published: (2019)

Zerumbone-loaded nanostructured lipid carrier induces apoptosis in human colorectal adenocarcinoma (Caco2) cell line
by: Nathaniel, Christian, et al.
Published: (2016)

The growth suppressing effects of Girinimbine on Hepg2 involve induction of apoptosis and cell cycle arrest.
by: Syam, Suvitha, et al.
Published: (2011)

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells
by: Inayat Hussain, Salmaan Hussain, et al.
Published: (2003)

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
by: De Smedt, Renate, et al.
Published: (2020)

Apoptosis induced by damnacanthal from morinda elliptica in T-lymphoblastic leukimia cell line (CEM-SS)
by: Abdul Hamid, Hisyam
Published: (2009)

In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea
by: Khalid, Bahariah, et al.
Published: (2024)

Effects of Damnacanthal, Nordamnacanthal, Betulinic Acid and Zerumbone Isolated from Local Medicinal Plants on Leukemia Cell Lines and Immune Cells
by: Abd Rahman, Mashitoh
Published: (2007)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

A phenylbutenoid dimer, cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3′′′,4′′′-dimethoxystyryl] cyclohex-1-ene, exhibits apoptogenic properties in T-acute lymphoblastic leukemia cells via induction of p53-independent mitochondrial signalling pathway
by: Anasamy, Theebaa, et al.
Published: (2013)

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest
by: Ng, Kuan Beng, et al.
Published: (2013)

In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa)
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)