Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line

QR Code

Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line

This investigation evaluated the antileukemia properties of a zerumbone (ZER)-loaded nanostructured lipid carrier (NLC) prepared by hot high-pressure homogenization techniques in an acute human lymphoblastic leukemia (Jurkat) cell line in vitro. The apoptogenic effect of the ZER-NLC on Jurkat cells...

Full description

Bibliographic Details
Main Authors:	Rahman, Heshu Sulaiman, Abdullah, Rasedee, Abdul, Ahmad Bustamam, Allaudin, Zeenathul Nazariah, Othman, Hemn Hassan, Yeap, Swee Keong, How, Chee Wun, Wan Abd Ghani, Wan Nor Hafiza
Format:	Article
Language:	English
Published:	Dove Medical Press 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/36045/ http://psasir.upm.edu.my/id/eprint/36045/1/36045.pdf

Similar Items

Zerumbone induces apoptosis in human acute leukemia Jurkat T-cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Zerumbone induces apoptosis in Jurkat T-cell line via activation of caspase 3 and caspase 9
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model
by: Rahman, Heshu Sulaiman, et al.
Published: (2015)

Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
by: Abdul Samad, Nozlena, et al.
Published: (2014)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
by: Rahman, Heshu Sulaiman, et al.
Published: (2013)

Increased regulatory T cells in acute lymphoblastic leukemia patients
by: Idris, Siti Zuleha, et al.
Published: (2015)

Zerumbone-loaded nanostructured lipid carrier induces apoptosis of canine mammary Adenocarcinoma cells
by: Foong, Jia Ning, et al.
Published: (2018)

Apoptosis pathways induced by recombinant adenovirus in cancer cells
by: Koh, Choo Yan, et al.
Published: (2010)

A composition for treating leukemia
by: Abdullah, Rasedee, et al.
Published: (2013)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Apoptosis induction in human leukemia cell lines by gold nanoparticles synthesized using the green biosynthetic approach
by: Namvar, Farideh, et al.
Published: (2015)

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.
by: Matthijssens, Filip, et al.
Published: (2021)

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution
by: Anderson, D., et al.
Published: (2020)

Anticancer potential of Damnacanthal and Nordamnacanthal from Morinda elliptica roots on T-lymphoblastic leukemia cells
by: Saiful Yazan, Latifah, et al.
Published: (2021)

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
by: Syam, Suvitha, et al.
Published: (2014)

Kenaf seed oil from supercritical carbon dioxide fluid extraction induced G1 phase cell cycle arrest and apoptosis in leukemia cells
by: Foo, Jhi Biau, et al.
Published: (2011)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway
by: Waziri, Peter M., et al.
Published: (2016)

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.
by: Roels, Juliette, et al.
Published: (2020)

Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo
by: Mohan, Syam, et al.
Published: (2010)

Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2007)

Pereskia bleo leaves extract induces cell death via cell cycle arrest and apoptosis in cervical cancer cells hela
by: Salleh, Siti Farhanah Mohd, et al.
Published: (2019)

Zerumbone nanoparticle preparation and characterization
by: Rahman, Heshu, et al.
Published: (2015)

Zerumbone-loaded nanostructured lipid carrier induces apoptosis in human colorectal adenocarcinoma (Caco2) cell line
by: Nathaniel, Christian, et al.
Published: (2016)

Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells
by: Inayat Hussain, Salmaan Hussain, et al.
Published: (2003)

The growth suppressing effects of Girinimbine on Hepg2 involve induction of apoptosis and cell cycle arrest.
by: Syam, Suvitha, et al.
Published: (2011)

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
by: De Smedt, Renate, et al.
Published: (2020)

Apoptosis induced by damnacanthal from morinda elliptica in T-lymphoblastic leukimia cell line (CEM-SS)
by: Abdul Hamid, Hisyam
Published: (2009)

In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea
by: Khalid, Bahariah, et al.
Published: (2024)

A phenylbutenoid dimer, cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3′′′,4′′′-dimethoxystyryl] cyclohex-1-ene, exhibits apoptogenic properties in T-acute lymphoblastic leukemia cells via induction of p53-independent mitochondrial signalling pathway
by: Anasamy, Theebaa, et al.
Published: (2013)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

Effects of Damnacanthal, Nordamnacanthal, Betulinic Acid and Zerumbone Isolated from Local Medicinal Plants on Leukemia Cell Lines and Immune Cells
by: Abd Rahman, Mashitoh
Published: (2007)

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest
by: Ng, Kuan Beng, et al.
Published: (2013)

In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa)
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Amelioration of human acute lymphoblastic leukemia (ALL) cells by ZnO-TiO2-Chitosan-Amygdalin nanocomposites
by: Elderdery, Abozer Y., et al.
Published: (2022)

Apoptosis and tumour cell death in response to pro-apoptotic gene
by: Nik Abd Rahman, Nik Mohd Afizan, et al.
Published: (2011)

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
by: Alshwyeh, Hussah Abdullah, et al.
Published: (2024)