Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line

QR Code

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line

This investigation determined the anticancer properties of zerumbone (ZER) on the human T-cell (Jurkat) line using the MTT assay, microscopic evaluations, flow cytometric analyses, and caspase activity estimations. The results showed that ZER is selectively cytotoxic to Jurkat cells in a dose and ti...

Full description

Bibliographic Details
Main Authors:	Rahman, Heshu Sulaiman, Abdullah, Rasedee, Chartrand, Max Stanley, Othman, Hemn Hassan, Yeap, Swee Keong, Namvar, Farideh
Format:	Article
Published:	Natural Product 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/36044/

Similar Items

Zerumbone induces apoptosis in human acute leukemia Jurkat T-cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Zerumbone induces apoptosis in Jurkat T-cell line via activation of caspase 3 and caspase 9
by: Rahman, Heshu Sulaiman, et al.
Published: (2012)

Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Apoptosis induction in human leukemia cell lines by gold nanoparticles synthesized using the green biosynthetic approach
by: Namvar, Farideh, et al.
Published: (2015)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
by: Abdul Samad, Nozlena, et al.
Published: (2014)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model
by: Rahman, Heshu Sulaiman, et al.
Published: (2015)

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway
by: Waziri, Peter M., et al.
Published: (2016)

Cytotoxic effects of bio-synthesized zinc oxide nanoparticles on murine cell lines
by: Namvar, Farideh, et al.
Published: (2014)

Anti-leukemic effects of zerumbone nanoparticle on human jurkat T lymphoblastoid cell lines in vitro and murine leukemic WEHI-3B model in vivo
by: Muhammad, Heshu Sulaiman Rahman
Published: (2014)

Acute toxicity study of zerumbone-loaded nanostructured lipid carrier on BALB/c mice model
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells
by: Inayat-Hussain, Salmaan H., et al.
Published: (1999)

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways
by: Foo, Jhi Biau, et al.
Published: (2014)

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signaling pathways
by: Foo, Jhi Biau, et al.
Published: (2014)

Zerumbone-loaded nanostructured lipid carrier induces apoptosis of canine mammary Adenocarcinoma cells
by: Foong, Jia Ning, et al.
Published: (2018)

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
by: Syam, Suvitha, et al.
Published: (2014)

Pomegranate juice induced cell cycle arrest and apoptosis through mitochondria pathway in human lung adenocarcinoma cells
by: Abdul Ghani, Radiah, et al.
Published: (2018)

Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits
by: Othman, Hemn Hassan, et al.
Published: (2015)

Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Piper sarmentosum induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016)

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest
by: Ng, Kuan Beng, et al.
Published: (2013)

Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract
by: Namvar, Farideh, et al.
Published: (2014)

Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2007)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
by: Rahman, Heshu Sulaiman, et al.
Published: (2013)

Zerumbone nanoparticle preparation and characterization
by: Rahman, Heshu, et al.
Published: (2015)

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

Piper sarmentosum (Daun kaduk) induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016)

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer
by: Prasannan, R., et al.
Published: (2012)

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
by: Alshwyeh, Hussah Abdullah, et al.
Published: (2024)

Porcupine bezoar exhibit cell cycle arrest through inhibiting cyclin /CDK1 complex and apoptosis mitochondria mediated dependent pathway in A549 cells
by: Firus Khan, Al'aina Yuhainis, et al.
Published: (2016)

Apoptosis pathways induced by recombinant adenovirus in cancer cells
by: Koh, Choo Yan, et al.
Published: (2010)

Effects Of Catharanthus Roseus Aqueous Extract On Jurkat Cells And Normal Peripheral Blood Mononuclear Cells
by: Ahmad, Nor Hazwani
Published: (2013)

Pyranocycloartobiloxanthone a suppressed metastasis ovarian cancer cells via s phase cell cycle arrest and apoptosis
by: Mashitoh Abd Rahman,, et al.
Published: (2023)

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells
by: Cai, F., et al.
Published: (2016)

Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin.
by: Ho, Ket Li, et al.
Published: (2009)

Flavokawain Derivative FLS Induced G2/M Arrest and Apoptosis on Breast Cancer MCF-7 Cell Line
by: Norlaily, Mohd Ali, et al.
Published: (2016)