Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus
Objective To evaluate the toxicological aspects of Nigella sativa (N. sativa) lipid and volatile fractions in streptozotocin induced diabetes mellitus. Methods National Institute of Health (NIH), Islamabad provided us thirty Sprague Dawley rats that were further divided into three groups, i.e. co...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35879/ |
| _version_ | 1848848177767120896 |
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| author | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Ahmad, Atif Nisar Suleria, Hafiz Ansar Rasul Saddique, Muhammad Suffyan |
| author_facet | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Ahmad, Atif Nisar Suleria, Hafiz Ansar Rasul Saddique, Muhammad Suffyan |
| author_sort | Sultan, Muhammad Tauseef |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective
To evaluate the toxicological aspects of Nigella sativa (N. sativa) lipid and volatile fractions in streptozotocin induced diabetes mellitus.
Methods
National Institute of Health (NIH), Islamabad provided us thirty Sprague Dawley rats that were further divided into three groups, i.e. control, N. sativa lipid fraction (4%) and N. sativa volatile fraction (0.3%), respectively. The serological and haematological indices were evaluated at 4-week intervals during 56 d study.
Results
The results indicated that the diabetes mellitus imparted negative effects on various serological and haematological attributes. However, supplementation of the N. sativa lipid fraction and N. sativa volatile fraction ameliorated the adverse consequences of diabetes mellitus. The diabetes induced renal toxicity and imbalanced serum chemistry were slightly modulated by experimental diets. However, the impact of essential oil was more significant as compared to the fixed oil.
Conclusions
In a nutshell, experimental diets containing N. sativa lipid fraction and N. sativa volatile fraction are effective without having any toxicological effects, and experimental diets reduced toxicological and adverse consequences of diabetes mellitus. |
| first_indexed | 2025-11-15T09:30:22Z |
| format | Article |
| id | upm-35879 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:30:22Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-358792016-02-11T04:40:09Z http://psasir.upm.edu.my/id/eprint/35879/ Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Ahmad, Atif Nisar Suleria, Hafiz Ansar Rasul Saddique, Muhammad Suffyan Objective To evaluate the toxicological aspects of Nigella sativa (N. sativa) lipid and volatile fractions in streptozotocin induced diabetes mellitus. Methods National Institute of Health (NIH), Islamabad provided us thirty Sprague Dawley rats that were further divided into three groups, i.e. control, N. sativa lipid fraction (4%) and N. sativa volatile fraction (0.3%), respectively. The serological and haematological indices were evaluated at 4-week intervals during 56 d study. Results The results indicated that the diabetes mellitus imparted negative effects on various serological and haematological attributes. However, supplementation of the N. sativa lipid fraction and N. sativa volatile fraction ameliorated the adverse consequences of diabetes mellitus. The diabetes induced renal toxicity and imbalanced serum chemistry were slightly modulated by experimental diets. However, the impact of essential oil was more significant as compared to the fixed oil. Conclusions In a nutshell, experimental diets containing N. sativa lipid fraction and N. sativa volatile fraction are effective without having any toxicological effects, and experimental diets reduced toxicological and adverse consequences of diabetes mellitus. Elsevier 2014-09 Article PeerReviewed Sultan, Muhammad Tauseef and Butt, Masood Sadiq and Karim, Roselina and Ahmad, Atif Nisar and Suleria, Hafiz Ansar Rasul and Saddique, Muhammad Suffyan (2014) Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus. Asian Pacific Journal of Tropical Disease, 4 (suppl. 2). S693-S697. ISSN 2222-1808 http://www.sciencedirect.com/science/article/pii/S222218081460709X 10.1016/S2222-1808(14)60709-X |
| spellingShingle | Sultan, Muhammad Tauseef Butt, Masood Sadiq Karim, Roselina Ahmad, Atif Nisar Suleria, Hafiz Ansar Rasul Saddique, Muhammad Suffyan Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title | Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title_full | Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title_fullStr | Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title_full_unstemmed | Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title_short | Toxicological and safety evaluation of Nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| title_sort | toxicological and safety evaluation of nigella sativa lipid and volatile fractions in streptozotocin induced diabetes mellitus |
| url | http://psasir.upm.edu.my/id/eprint/35879/ http://psasir.upm.edu.my/id/eprint/35879/ http://psasir.upm.edu.my/id/eprint/35879/ |