The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities
Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe2+ and Fe3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocompos...
| Main Authors: | , , , , , |
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| Format: | Article |
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Dove Medical Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35622/ |
| _version_ | 1848848106430398464 |
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| author | El Zowalaty, Mohamed Ezzat Hussein-Al-Ali, Samer Hassan Husseiny, Mohamed I. Geilich, Benjamin M. Webster, Thomas Jay Hussein, Mohd Zobir |
| author_facet | El Zowalaty, Mohamed Ezzat Hussein-Al-Ali, Samer Hassan Husseiny, Mohamed I. Geilich, Benjamin M. Webster, Thomas Jay Hussein, Mohd Zobir |
| author_sort | El Zowalaty, Mohamed Ezzat |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe2+ and Fe3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocomposites were subsequently characterized using X-ray diffraction and were evaluated for their antibacterial activity. The antimicrobial activity of the as-synthesized nanoparticles was evaluated using different Gram-positive and Gram-negative bacteria, as well as Mycobacterium tuberculosis. For the first time, it was found that the nanoparticles showed antimicrobial activities against the tested microorganisms (albeit with a more pronounced effect against Gram-negative than Gram-positive bacteria), and thus, should be further studied as a novel nano-antibiotic for numerous antimicrobial and antituberculosis applications. Moreover, since these nanoparticle bacteria fighters are magnetic, one can easily envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand. Due to the ability of magnetic nanoparticles to increase the sensitivity of imaging modalities (such as magnetic resonance imaging), these novel nanoparticles can also be used to diagnose the presence of such microorganisms. In summary, although requiring further investigation, this study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections. |
| first_indexed | 2025-11-15T09:29:13Z |
| format | Article |
| id | upm-35622 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:29:13Z |
| publishDate | 2015 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-356222016-01-18T02:59:03Z http://psasir.upm.edu.my/id/eprint/35622/ The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities El Zowalaty, Mohamed Ezzat Hussein-Al-Ali, Samer Hassan Husseiny, Mohamed I. Geilich, Benjamin M. Webster, Thomas Jay Hussein, Mohd Zobir Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe2+ and Fe3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocomposites were subsequently characterized using X-ray diffraction and were evaluated for their antibacterial activity. The antimicrobial activity of the as-synthesized nanoparticles was evaluated using different Gram-positive and Gram-negative bacteria, as well as Mycobacterium tuberculosis. For the first time, it was found that the nanoparticles showed antimicrobial activities against the tested microorganisms (albeit with a more pronounced effect against Gram-negative than Gram-positive bacteria), and thus, should be further studied as a novel nano-antibiotic for numerous antimicrobial and antituberculosis applications. Moreover, since these nanoparticle bacteria fighters are magnetic, one can easily envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand. Due to the ability of magnetic nanoparticles to increase the sensitivity of imaging modalities (such as magnetic resonance imaging), these novel nanoparticles can also be used to diagnose the presence of such microorganisms. In summary, although requiring further investigation, this study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections. Dove Medical Press 2015 Article PeerReviewed El Zowalaty, Mohamed Ezzat and Hussein-Al-Ali, Samer Hassan and Husseiny, Mohamed I. and Geilich, Benjamin M. and Webster, Thomas Jay and Hussein, Mohd Zobir (2015) The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities. International Journal of Nanomedicine, 10. 3269-3274 . ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/the-ability-of-streptomycin-loaded-chitosan-coated-magnetic-nanocompos-peer-reviewed-article-IJN 10.2147/IJN.S74469 |
| spellingShingle | El Zowalaty, Mohamed Ezzat Hussein-Al-Ali, Samer Hassan Husseiny, Mohamed I. Geilich, Benjamin M. Webster, Thomas Jay Hussein, Mohd Zobir The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title | The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title_full | The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title_fullStr | The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title_full_unstemmed | The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title_short | The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| title_sort | ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities |
| url | http://psasir.upm.edu.my/id/eprint/35622/ http://psasir.upm.edu.my/id/eprint/35622/ http://psasir.upm.edu.my/id/eprint/35622/ |