Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method an...
| Main Authors: | , , , , |
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| Format: | Article |
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Dove Medical Press
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35585/ |
| _version_ | 1848848096472072192 |
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| author | Hussein-Al-Ali, Samer Hasan El Zowalaty, Mohamed Ezzat Hussein, Mohd. Zobir Ismail, Maznah Webster, Thomas Jay |
| author_facet | Hussein-Al-Ali, Samer Hasan El Zowalaty, Mohamed Ezzat Hussein, Mohd. Zobir Ismail, Maznah Webster, Thomas Jay |
| author_sort | Hussein-Al-Ali, Samer Hasan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections. |
| first_indexed | 2025-11-15T09:29:04Z |
| format | Article |
| id | upm-35585 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:29:04Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-355852016-01-18T01:26:24Z http://psasir.upm.edu.my/id/eprint/35585/ Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic Hussein-Al-Ali, Samer Hasan El Zowalaty, Mohamed Ezzat Hussein, Mohd. Zobir Ismail, Maznah Webster, Thomas Jay This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections. Dove Medical Press 2014 Article PeerReviewed Hussein-Al-Ali, Samer Hasan and El Zowalaty, Mohamed Ezzat and Hussein, Mohd. Zobir and Ismail, Maznah and Webster, Thomas Jay (2014) Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic. International Journal of Nanomedicine, 9 (1). pp. 549-557. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/synthesis-characterization-controlled-release-and-antibacterial-studie-peer-reviewed-article-IJN 10.2147/IJN.S53079 |
| spellingShingle | Hussein-Al-Ali, Samer Hasan El Zowalaty, Mohamed Ezzat Hussein, Mohd. Zobir Ismail, Maznah Webster, Thomas Jay Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title | Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title_full | Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title_fullStr | Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title_full_unstemmed | Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title_short | Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| title_sort | synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic |
| url | http://psasir.upm.edu.my/id/eprint/35585/ http://psasir.upm.edu.my/id/eprint/35585/ http://psasir.upm.edu.my/id/eprint/35585/ |