Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments
Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. CSCs persist in tumors as...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Wiley
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35537/ |
| _version_ | 1848848082668617728 |
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| author | Kao, Ta Chun Lee, Henry Hsin Chung Higuchi, Akon Ling, Qing Dong Yu, Wan Chun Chou, Yu Hsuan Wang, Pin Yu Kumar, S. Suresh Chang, Yu Chen, Yung Hung Chang, Yung Chen, Da Chung Hsu, Shih Tien |
| author_facet | Kao, Ta Chun Lee, Henry Hsin Chung Higuchi, Akon Ling, Qing Dong Yu, Wan Chun Chou, Yu Hsuan Wang, Pin Yu Kumar, S. Suresh Chang, Yu Chen, Yung Hung Chang, Yung Chen, Da Chung Hsu, Shih Tien |
| author_sort | Kao, Ta Chun |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumorigenic clones. The purification or depletion (suppression) of CSCs should be useful for analyzing CSC characteristics and for clinical application. CSCs can be selectively suppressed from colon cancer cells containing adipose-derived stem cells (ADSCs) on Pluronic-grafted dishes, while ADSCs remain on the dishes. ADSCs on Pluronic-grafted dishes after the suppression of the CSCs can differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, and neuronal cells. The CSCs and ADSCs exhibited different characteristics. The selection of ADSCs was possible on Pluronic-grafted dishes that suppressed the CSCs from the fat tissues of cancer patients (i.e., cell-sorting dishes), which was explained by specific biomedical characteristics of Pluronic. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 463–476, 2014. |
| first_indexed | 2025-11-15T09:28:51Z |
| format | Article |
| id | upm-35537 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:28:51Z |
| publishDate | 2014 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-355372016-01-14T03:42:00Z http://psasir.upm.edu.my/id/eprint/35537/ Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments Kao, Ta Chun Lee, Henry Hsin Chung Higuchi, Akon Ling, Qing Dong Yu, Wan Chun Chou, Yu Hsuan Wang, Pin Yu Kumar, S. Suresh Chang, Yu Chen, Yung Hung Chang, Yung Chen, Da Chung Hsu, Shih Tien Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumorigenic clones. The purification or depletion (suppression) of CSCs should be useful for analyzing CSC characteristics and for clinical application. CSCs can be selectively suppressed from colon cancer cells containing adipose-derived stem cells (ADSCs) on Pluronic-grafted dishes, while ADSCs remain on the dishes. ADSCs on Pluronic-grafted dishes after the suppression of the CSCs can differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, and neuronal cells. The CSCs and ADSCs exhibited different characteristics. The selection of ADSCs was possible on Pluronic-grafted dishes that suppressed the CSCs from the fat tissues of cancer patients (i.e., cell-sorting dishes), which was explained by specific biomedical characteristics of Pluronic. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 463–476, 2014. Wiley 2014-04 Article PeerReviewed Kao, Ta Chun and Lee, Henry Hsin Chung and Higuchi, Akon and Ling, Qing Dong and Yu, Wan Chun and Chou, Yu Hsuan and Wang, Pin Yu and Kumar, S. Suresh and Chang, Yu and Chen, Yung Hung and Chang, Yung and Chen, Da Chung and Hsu, Shih Tien (2014) Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments. Journal of Biomedical Materials Research Part B: Applied Biomaterial, 102 (3). pp. 463-476. ISSN 1552-4973; ESSN: 1552-4981 http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33024/abstract 10.1002/jbm.b.33024 |
| spellingShingle | Kao, Ta Chun Lee, Henry Hsin Chung Higuchi, Akon Ling, Qing Dong Yu, Wan Chun Chou, Yu Hsuan Wang, Pin Yu Kumar, S. Suresh Chang, Yu Chen, Yung Hung Chang, Yung Chen, Da Chung Hsu, Shih Tien Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title_full | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title_fullStr | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title_full_unstemmed | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title_short | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| title_sort | suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| url | http://psasir.upm.edu.my/id/eprint/35537/ http://psasir.upm.edu.my/id/eprint/35537/ http://psasir.upm.edu.my/id/eprint/35537/ |