Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors
Objective. To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors. Methods. Forty RA patients with matched age and gender healthy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/35521/ http://psasir.upm.edu.my/id/eprint/35521/1/Subclinical%20atherosclerosis%20among%20rheumatoid%20arthritis%20patients%20without%20overt%20cardiovascular%20risk%20factors.pdf |
| _version_ | 1848848078468022272 |
|---|---|
| author | Sulaiman Sahari, Narisa Shaharir, Syahrul Sazliyana Ismail, Mohd Redzuan Rajalingham, Sakthiswary Mohamed Said, Mohd Shahrir |
| author_facet | Sulaiman Sahari, Narisa Shaharir, Syahrul Sazliyana Ismail, Mohd Redzuan Rajalingham, Sakthiswary Mohamed Said, Mohd Shahrir |
| author_sort | Sulaiman Sahari, Narisa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective. To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors.
Methods. Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT.
Results. Abnormally thickened CIMT were observed in 11 RA patients (27.5%) and in 4 control subjects (10%), p = 0.04. It was highly prevalent among RA patients with active disease (54.5% vs 17.2%), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT.
Conclusions. RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it. |
| first_indexed | 2025-11-15T09:28:47Z |
| format | Article |
| id | upm-35521 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:28:47Z |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-355212016-01-27T04:49:34Z http://psasir.upm.edu.my/id/eprint/35521/ Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors Sulaiman Sahari, Narisa Shaharir, Syahrul Sazliyana Ismail, Mohd Redzuan Rajalingham, Sakthiswary Mohamed Said, Mohd Shahrir Objective. To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors. Methods. Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT. Results. Abnormally thickened CIMT were observed in 11 RA patients (27.5%) and in 4 control subjects (10%), p = 0.04. It was highly prevalent among RA patients with active disease (54.5% vs 17.2%), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT. Conclusions. RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it. Taylor & Francis 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35521/1/Subclinical%20atherosclerosis%20among%20rheumatoid%20arthritis%20patients%20without%20overt%20cardiovascular%20risk%20factors.pdf Sulaiman Sahari, Narisa and Shaharir, Syahrul Sazliyana and Ismail, Mohd Redzuan and Rajalingham, Sakthiswary and Mohamed Said, Mohd Shahrir (2014) Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors. Modern Rheumatology, 24 (6). pp. 920-925. ISSN 1439-7595; ESSN: 1439-7609 http://www.tandfonline.com/doi/abs/10.3109/14397595.2014.891497?journalCode=imor20 10.3109/14397595.2014.891497 |
| spellingShingle | Sulaiman Sahari, Narisa Shaharir, Syahrul Sazliyana Ismail, Mohd Redzuan Rajalingham, Sakthiswary Mohamed Said, Mohd Shahrir Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title | Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title_full | Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title_fullStr | Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title_full_unstemmed | Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title_short | Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| title_sort | subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors |
| url | http://psasir.upm.edu.my/id/eprint/35521/ http://psasir.upm.edu.my/id/eprint/35521/ http://psasir.upm.edu.my/id/eprint/35521/ http://psasir.upm.edu.my/id/eprint/35521/1/Subclinical%20atherosclerosis%20among%20rheumatoid%20arthritis%20patients%20without%20overt%20cardiovascular%20risk%20factors.pdf |