Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application
This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which se...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35448/ http://psasir.upm.edu.my/id/eprint/35448/1/Stability%20of%20Positively%20Charged%20Nanoemulsion.pdf |
| _version_ | 1848848057965215744 |
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| author | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon |
| author_facet | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon |
| author_sort | Da Costa, Stephanie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application. |
| first_indexed | 2025-11-15T09:28:27Z |
| format | Article |
| id | upm-35448 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:28:27Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-354482016-01-11T02:07:05Z http://psasir.upm.edu.my/id/eprint/35448/ Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35448/1/Stability%20of%20Positively%20Charged%20Nanoemulsion.pdf Da Costa, Stephanie and Basri, Mahiran and Shamsudin, Norashikin and Basri, Hamidon (2014) Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application. Journal of Chemistry, 2014. art. no. 748680. pp. 1-8. ISSN 2090-9063; ESSN: 2090-9071 http://www.hindawi.com/journals/jchem/2014/748680/abs/ 10.1155/2014/748680 |
| spellingShingle | Da Costa, Stephanie Basri, Mahiran Shamsudin, Norashikin Basri, Hamidon Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title | Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title_full | Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title_fullStr | Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title_full_unstemmed | Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title_short | Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| title_sort | stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| url | http://psasir.upm.edu.my/id/eprint/35448/ http://psasir.upm.edu.my/id/eprint/35448/ http://psasir.upm.edu.my/id/eprint/35448/ http://psasir.upm.edu.my/id/eprint/35448/1/Stability%20of%20Positively%20Charged%20Nanoemulsion.pdf |