SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells

QR Code

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells

Purpose 3,19-(3-Chloro-4-fluorobenzylidene)andrographolide (SRJ23), a new semisynthetic derivative of andrographolide (AGP), exhibited selectivity against prostate cancer cells in the US National Cancer Institute (NCI) in vitro anti-cancer screen. Herein, we report the in vitro growth inhibition an...

Full description

Bibliographic Details
Main Authors:	Wong, Hui Chyn, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Loke, Seng Cheong, Lajis, Nordin, Stanslas, Johnson
Format:	Article
Published:	Springer 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/35445/

Similar Items

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

In vitro growth inhibition, molecular mechanisms of cell cycle arrest, and apoptosis in prostate cancer cells by SRJ23
by: Wong, Hui Chyn
Published: (2013)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
by: Wong, Charng Choon, et al.
Published: (2014)

Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
by: Shun, Ying Quah, et al.
Published: (2021)

Elucidation of anticancer activity mechanism of 3,19-(2-Bromobenzylidene) andrographolide (SRJ09) in breast and colon cancer cells
by: Wong, Charng Choon
Published: (2016)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide
by: Wong, Charng Choon, et al.
Published: (2014)

SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
by: Wong, Charng Choon, et al.
Published: (2016)

SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
by: Lim, Jonathan Chee Woei, et al.
Published: (2015)

Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets
by: Stanslas, Johnson, et al.
Published: (2010)

Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis
by: Jada, Srinivasa Rao, et al.
Published: (2008)

Cytotoxicity of SRJ23 and its derivatives, expression and SRJ23 binding of KRas G12V oncoprotein
by: Tan, Michelle Siying
Published: (2017)

In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea
by: Khalid, Bahariah, et al.
Published: (2024)

Mechanisms of Antitumour Activity of 3,19-(2 Bromobenzylidene) Andrographolide (SRJ09)
by: Lim, Siang Hui
Published: (2007)

Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
by: Manikam, Shiamala Devi, et al.
Published: (2009)

Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
by: Soo, Hon Liong, et al.
Published: (2019)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

New semisynthetic andrographolide and 14-Deoxy-11, 12-didehydroandrographolide derivatives with anticancer, anti-histamine and nitric oxide inhibitory activities
by: Jeyaraj Asirvatham, Ethel Jeyaseela
Published: (2016)

A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model
by: Lim, J. C. W., et al.
Published: (2016)

Synthesis and Characterization of Semisynthetic Metallothermolysin
by: Khalid, Syarajatul Erma
Published: (2008)

Pyranocycloartobiloxanthone a suppressed metastasis ovarian cancer cells via s phase cell cycle arrest and apoptosis
by: Mashitoh Abd Rahman,, et al.
Published: (2023)

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells
by: Cai, F., et al.
Published: (2016)

Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin.
by: Ho, Ket Li, et al.
Published: (2009)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
by: Hocker, Harrison J., et al.
Published: (2013)

Pharmacological modulation of apoptosis and autophagy in pancreatic cancer treatment
by: Stanslas, Johnson, et al.
Published: (2022)

Pomegranate juice induced cell cycle arrest and apoptosis through mitochondria pathway in human lung adenocarcinoma cells
by: Abdul Ghani, Radiah, et al.
Published: (2018)

Pereskia bleo leaves extract induces cell death via cell cycle arrest and apoptosis in cervical cancer cells hela
by: Salleh, Siti Farhanah Mohd, et al.
Published: (2019)

Inhibitory Effects Of Andrographolide In Pc-3 Cell Line And The Induction Of Apoptosis Via The Involvement Of Caspases 3, 8 And 9
by: Manimaran, Janany
Published: (2023)

In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein
by: Shun, Ying Quah, et al.
Published: (2020)

Camellia sinensis and Phyllanthus amarus ethanol extracts induced apoptosis and cell cycle arrest on human leukemic cell lines
by: Syaratul Dalina Yusoff,, et al.
Published: (2022)

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

The growth suppressing effects of Girinimbine on Hepg2 involve induction of apoptosis and cell cycle arrest.
by: Syam, Suvitha, et al.
Published: (2011)

Nordamnacanthal induced apoptosis and mitotic-G2/M arrest with downregulation of Bcl-2 in the human breast cancer cell line (MCF-7).
by: Ishak , Norsyafini, et al.
Published: (2010)

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
by: Alshwyeh, Hussah Abdullah, et al.
Published: (2024)

Cytotoxicity, cell cycle arrest, and apoptosis in breast cancer cell lines exposed to an extract of the seed kernel of Mangifera pajang (bambangan).
by: Abu Bakar, Mohd Fadzelly, et al.
Published: (2010)

Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line
by: Moghaddam, Amin Boroumand, et al.
Published: (2017)

Semisynthesis and in vitro anticancer activities of andrographolide analogues
by: Jada, Srinivasa Rao, et al.
Published: (2007)

Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells
by: Mohd Esa, Norhaizan, et al.
Published: (2010)

Apoptosis and cell cycle arrest of MCF-7R breast carcinoma cells by bis(phosphane)copper(I) thiocarbamides derivative compounds
by: Ooi, Kah Kooi
Published: (2017)

Protein Structure-Based Design of Novel Semisynthetic Metallotrypsin
by: Misran, Azizah
Published: (2006)

Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)₂ towards oestrogen-receptor positive MCF-7 breast cancer cells
by: Jhi, Biau Foo, et al.
Published: (2019)