Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer

QR Code

Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer

Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Tr...

Full description

Bibliographic Details
Main Authors:	Pandurangan, Ashok Kumar, Mohd Esa, Norhaizan
Format:	Article
Published:	Asian Pacific Education Press Ltd. 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/35368/

Similar Items

Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Molecular targets of colorectal cancer: an insight on intracellular cellular signaling pathways
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
by: Arora, L., et al.
Published: (2018)

Dietary non-nutritive factors on molecular targets of colorectal cancer: an update
by: Pandurangan, Ashok Kumar, et al.
Published: (2013)

Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets
by: Pandurangan, Ashok Kumar, et al.
Published: (2016)

Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Caffeic acid phenethyl ester attenuates dextran sulfate sodium-induced ulcerative colitis through modulation of NF-κB and cell adhesion molecules
by: Pandurangan, Ashok Kumar, et al.
Published: (2022)

Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: possible mechanisms
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer
by: Zhang, J., et al.
Published: (2017)

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
by: Rajendran, P., et al.
Published: (2011)

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
by: Subramaniam, A., et al.
Published: (2012)

Development of a novel azaspirane that targets the Janus Kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo
by: Mohan, C., et al.
Published: (2014)

Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
by: Siveen, K., et al.
Published: (2014)

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
by: Rajendran, P., et al.
Published: (2012)

Isolation and characterization of lectin from the Artist’s Conk medicinal mushroom, Ganoderma applanatum (Agaricomycetes) and evaluation of its antiproliferative activity in HT-29 colon cancer cells
by: Kumaran, Sekar, et al.
Published: (2017)

Manilkara zapota (L.) P. royen leaf mitigates colitis-associated colon cancer through anti-inflammatory modulation in BALB/C Mice
by: Mohd Esa, Norhaizan, et al.
Published: (2024)

Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia
by: Muhamad, Izyan Rifhana
Published: (2023)

Targeting transcription factor STAT3 for cancer prevention and therapy.
by: Chai, E., et al.
Published: (2015)

Effects of cocoa polyphenol rich diet in prevention of colitis-associated colon cancer
by: Saadatdoust, Zeinab
Published: (2015)

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies
by: Wong, A., et al.
Published: (2015)

NHE-1: A promising target for novel anti-cancer therapeutics
by: Loo, S., et al.
Published: (2012)

Chemopreventive effects of citrus hystrix leaf ethanolic extract on colitis-associated cancer in mice
by: Mohd Ishak, Nur Ilyani
Published: (2020)

Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells
by: Pandurangan, Ashok Kumar, et al.
Published: (2018)

Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats
by: Hu, Y., et al.
Published: (2015)

Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells
by: Shafie, Nurul Husna, et al.
Published: (2013)

Unusual association of diseases/symptoms: Sweet's syndrome in Crohn's colitis
by: Abdullah , Sheikh Anwar, et al.
Published: (2009)

Oh dear...it amoebic colitis.
by: Mohtarrudin, Norhafizah, et al.
Published: (2011)

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
by: Siveen, K., et al.
Published: (2013)

Investigating the initiation & progression of ulcerative colitis
by: Fair, Kathryn L.
Published: (2024)

Targeting PPARy signaling cascade for the prevention and treatment of prostate cancer
by: Sikka, S., et al.
Published: (2012)

Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways
by: Shafie, Nurul Husna, et al.
Published: (2013)

Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers
by: Teow, Sin Yeang *, et al.
Published: (2017)

Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
by: Awaad, Amani Shafeek, et al.
Published: (2017)

Amino acid transporters in breast cancer: promising prognostic markers and emerging targets across molecular subtypes
by: El Ansari, Rokaya
Published: (2020)

Cancer chemoprevention by nuts: Evidence and promises
by: Falasca, Marco, et al.
Published: (2012)

Unveiling common pathways and potential drug targets for ulcerative colitis and IgG4-related disease through bioinformatics analysis
by: Liao, Quan, et al.
Published: (2024)

Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer
by: Alcantara, M., et al.
Published: (2013)

Development and evaluation of selective nitroxanthone derivatives: a promising compound for targeting MCF-7 breast cancer cells
by: Devakrishnan, Pavithren, et al.
Published: (2025)