Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia
Rhabdomyolysis is a serious but rare side effect of Lamivudine treatment. Therefore, appropriate biochemical monitoring should be undertaken when it is used in the treatment of hepatitis B. This paper presents a case of Lamivudine-associated rhabdomyolysis in a 31-year-old man with congenital heart...
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| Format: | Article |
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Electronic Physician
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35271/ |
| _version_ | 1848848008066629632 |
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| author | Baharin, Janudin Sulaiman Sahari, Narisa Mohd Sazlly Lim, Sazlyna |
| author_facet | Baharin, Janudin Sulaiman Sahari, Narisa Mohd Sazlly Lim, Sazlyna |
| author_sort | Baharin, Janudin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Rhabdomyolysis is a serious but rare side effect of Lamivudine treatment. Therefore, appropriate biochemical monitoring should be undertaken when it is used in the treatment of hepatitis B. This paper presents a case of Lamivudine-associated rhabdomyolysis in a 31-year-old man with congenital heart disease and hepatitis B. Three days after starting Lamivudine, the patient developed myalgia. Significant muscle tenderness and swelling of the upper and lower limbs was discovered during a physical examination. Creatine kinase was markedly raised. Lamivudine-induced rhabdomyolysis was suspected and the drug was discontinued. Symptoms and creatine kinase activity improved within four days of Lamivudine cessation and hydration. Early identification of Lamivudine-induced rhabdomyolysis is key in preventing this potentially fatal drug reaction; withdrawal of Lamivudine may contribute to complete remission of rhabdomyolysis. |
| first_indexed | 2025-11-15T09:27:40Z |
| format | Article |
| id | upm-35271 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:27:40Z |
| publishDate | 2014 |
| publisher | Electronic Physician |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-352712015-12-31T04:45:29Z http://psasir.upm.edu.my/id/eprint/35271/ Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia Baharin, Janudin Sulaiman Sahari, Narisa Mohd Sazlly Lim, Sazlyna Rhabdomyolysis is a serious but rare side effect of Lamivudine treatment. Therefore, appropriate biochemical monitoring should be undertaken when it is used in the treatment of hepatitis B. This paper presents a case of Lamivudine-associated rhabdomyolysis in a 31-year-old man with congenital heart disease and hepatitis B. Three days after starting Lamivudine, the patient developed myalgia. Significant muscle tenderness and swelling of the upper and lower limbs was discovered during a physical examination. Creatine kinase was markedly raised. Lamivudine-induced rhabdomyolysis was suspected and the drug was discontinued. Symptoms and creatine kinase activity improved within four days of Lamivudine cessation and hydration. Early identification of Lamivudine-induced rhabdomyolysis is key in preventing this potentially fatal drug reaction; withdrawal of Lamivudine may contribute to complete remission of rhabdomyolysis. Electronic Physician 2014 Article PeerReviewed Baharin, Janudin and Sulaiman Sahari, Narisa and Mohd Sazlly Lim, Sazlyna (2014) Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia. Electronic Physician, 6 (3). pp. 863-867. ISSN 2008-5842 http://www.ephysician.ir/index.php/browse-issues/year-2014-volume-6/year-2014-volume-6-issue-3/129-rhabdomyolysis-due-to-lamivudine-administration-in-acute-viral-hepatitis-b-infection-a-case-report-from-malaysia 10.14661/2014.863-867 |
| spellingShingle | Baharin, Janudin Sulaiman Sahari, Narisa Mohd Sazlly Lim, Sazlyna Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title | Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title_full | Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title_fullStr | Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title_full_unstemmed | Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title_short | Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia |
| title_sort | rhabdomyolysis due to lamivudine administration in acute viral hepatitis b infection: a case report from malaysia |
| url | http://psasir.upm.edu.my/id/eprint/35271/ http://psasir.upm.edu.my/id/eprint/35271/ http://psasir.upm.edu.my/id/eprint/35271/ |