Metabolism of goniothalamin in animal and microbial system
Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, H...
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| Format: | Article |
| Language: | English |
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Societa Editoriale Farmaceutica
1996
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35035/ http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf |
| _version_ | 1848847941860589568 |
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| author | El-Sharkawy, Saleh Hassan Yusuf, Z. Lope Pihie, Azimahtol Hawariah Ali, Abdul Manaf |
| author_facet | El-Sharkawy, Saleh Hassan Yusuf, Z. Lope Pihie, Azimahtol Hawariah Ali, Abdul Manaf |
| author_sort | El-Sharkawy, Saleh Hassan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, HPLC, MS, IR, and 1H- and 13C-NMR spectroscopy. In addition, the substrate had been transformed into two unknown metabolites by Aspergillus niger ATCC 11394 and Septomyxa affinis ATCC 6737 in low yield. Three of the metabolites were also detected and identified in the urine and blood samples of the goniothalamin-treated Sprague-Dawley rats. The obtained results are in agreement with and support the principle of microbial models of mammalian metabolism. |
| first_indexed | 2025-11-15T09:26:37Z |
| format | Article |
| id | upm-35035 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:26:37Z |
| publishDate | 1996 |
| publisher | Societa Editoriale Farmaceutica |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-350352016-04-26T01:53:55Z http://psasir.upm.edu.my/id/eprint/35035/ Metabolism of goniothalamin in animal and microbial system El-Sharkawy, Saleh Hassan Yusuf, Z. Lope Pihie, Azimahtol Hawariah Ali, Abdul Manaf Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, HPLC, MS, IR, and 1H- and 13C-NMR spectroscopy. In addition, the substrate had been transformed into two unknown metabolites by Aspergillus niger ATCC 11394 and Septomyxa affinis ATCC 6737 in low yield. Three of the metabolites were also detected and identified in the urine and blood samples of the goniothalamin-treated Sprague-Dawley rats. The obtained results are in agreement with and support the principle of microbial models of mammalian metabolism. Societa Editoriale Farmaceutica 1996 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf El-Sharkawy, Saleh Hassan and Yusuf, Z. and Lope Pihie, Azimahtol Hawariah and Ali, Abdul Manaf (1996) Metabolism of goniothalamin in animal and microbial system. Bollettino Chimico Farmaceutico, 135 (1). pp. 35-40. ISSN 0006-6648 |
| spellingShingle | El-Sharkawy, Saleh Hassan Yusuf, Z. Lope Pihie, Azimahtol Hawariah Ali, Abdul Manaf Metabolism of goniothalamin in animal and microbial system |
| title | Metabolism of goniothalamin in animal and microbial system |
| title_full | Metabolism of goniothalamin in animal and microbial system |
| title_fullStr | Metabolism of goniothalamin in animal and microbial system |
| title_full_unstemmed | Metabolism of goniothalamin in animal and microbial system |
| title_short | Metabolism of goniothalamin in animal and microbial system |
| title_sort | metabolism of goniothalamin in animal and microbial system |
| url | http://psasir.upm.edu.my/id/eprint/35035/ http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf |