Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities
Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34940/ http://psasir.upm.edu.my/id/eprint/34940/1/Phytochemicals%20from%20Kaempferia%20angustifolia%20Rosc.%20and%20Their.pdf |
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| author | Tang, Sook Wah Sukari, Mohd Aspollah Neoh, Bee Keat Yeap, Yunie Soon Yu Abdul, Ahmad Bustamam Kifli, Nurolaini Ee, Gwendoline Cheng Lian |
| author_facet | Tang, Sook Wah Sukari, Mohd Aspollah Neoh, Bee Keat Yeap, Yunie Soon Yu Abdul, Ahmad Bustamam Kifli, Nurolaini Ee, Gwendoline Cheng Lian |
| author_sort | Tang, Sook Wah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), sucrose, -sitosterol, and its glycoside (8). The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR). Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), and -sitosterol-3-O- -D-glucopyranoside (8) from this plant species has never been reported previously. The spectroscopic data of (7) is firstly described in this paper. Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines. However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines. Similarly, none of the extracts or compounds showed activity in the antimicrobial testing. |
| first_indexed | 2025-11-15T09:26:10Z |
| format | Article |
| id | upm-34940 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:26:10Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-349402015-12-24T03:49:39Z http://psasir.upm.edu.my/id/eprint/34940/ Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities Tang, Sook Wah Sukari, Mohd Aspollah Neoh, Bee Keat Yeap, Yunie Soon Yu Abdul, Ahmad Bustamam Kifli, Nurolaini Ee, Gwendoline Cheng Lian Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), sucrose, -sitosterol, and its glycoside (8). The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR). Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), and -sitosterol-3-O- -D-glucopyranoside (8) from this plant species has never been reported previously. The spectroscopic data of (7) is firstly described in this paper. Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines. However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines. Similarly, none of the extracts or compounds showed activity in the antimicrobial testing. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34940/1/Phytochemicals%20from%20Kaempferia%20angustifolia%20Rosc.%20and%20Their.pdf Tang, Sook Wah and Sukari, Mohd Aspollah and Neoh, Bee Keat and Yeap, Yunie Soon Yu and Abdul, Ahmad Bustamam and Kifli, Nurolaini and Ee, Gwendoline Cheng Lian (2014) Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities. BioMed Research International, 2014. art. no. 417674. pp. 1-6. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/417674/abs/ 10.1155/2014/417674 |
| spellingShingle | Tang, Sook Wah Sukari, Mohd Aspollah Neoh, Bee Keat Yeap, Yunie Soon Yu Abdul, Ahmad Bustamam Kifli, Nurolaini Ee, Gwendoline Cheng Lian Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title | Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title_full | Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title_fullStr | Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title_full_unstemmed | Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title_short | Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities |
| title_sort | phytochemicals from kaempferia angustifolia rosc. and their cytotoxic and antimicrobial activities |
| url | http://psasir.upm.edu.my/id/eprint/34940/ http://psasir.upm.edu.my/id/eprint/34940/ http://psasir.upm.edu.my/id/eprint/34940/ http://psasir.upm.edu.my/id/eprint/34940/1/Phytochemicals%20from%20Kaempferia%20angustifolia%20Rosc.%20and%20Their.pdf |