Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Te...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34938/ http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf |
| _version_ | 1848847913574203392 |
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| author | Mftah, Ae Alhassan, Fatah H. Al-Qubaisi, Mothanna Sadiq El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Abdullah, Rasedee Yap, Taufiq Yun Hin Rashid, Shah Samiur |
| author_facet | Mftah, Ae Alhassan, Fatah H. Al-Qubaisi, Mothanna Sadiq El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Abdullah, Rasedee Yap, Taufiq Yun Hin Rashid, Shah Samiur |
| author_sort | Mftah, Ae |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. |
| first_indexed | 2025-11-15T09:26:10Z |
| format | Article |
| id | upm-34938 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:26:10Z |
| publishDate | 2015 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-349382016-11-28T02:36:13Z http://psasir.upm.edu.my/id/eprint/34938/ Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles Mftah, Ae Alhassan, Fatah H. Al-Qubaisi, Mothanna Sadiq El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Abdullah, Rasedee Yap, Taufiq Yun Hin Rashid, Shah Samiur Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. Dove Medical Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf Mftah, Ae and Alhassan, Fatah H. and Al-Qubaisi, Mothanna Sadiq and El Zowalaty, Mohamed Ezzat and Webster, Thomas Jay and Sh-Eldin, Mohammed Ali and Abdullah, Rasedee and Yap, Taufiq Yun Hin and Rashid, Shah Samiur (2015) Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles. International Journal of Nanomedicine, 10 (1). pp. 765-774. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/physicochemical-properties-cytotoxicity-andnbspantimicrobial-activity--peer-reviewed-article-IJN 10.2147/IJN.S66058 |
| spellingShingle | Mftah, Ae Alhassan, Fatah H. Al-Qubaisi, Mothanna Sadiq El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Abdullah, Rasedee Yap, Taufiq Yun Hin Rashid, Shah Samiur Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title | Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title_full | Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title_fullStr | Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title_full_unstemmed | Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title_short | Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| title_sort | physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles |
| url | http://psasir.upm.edu.my/id/eprint/34938/ http://psasir.upm.edu.my/id/eprint/34938/ http://psasir.upm.edu.my/id/eprint/34938/ http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf |