Pharmacologically antagonizing the CXCR4-CXCL12 chemokine pathway with AMD3100 inhibits sunlight-induced skin cancer

QR Code

Pharmacologically antagonizing the CXCR4-CXCL12 chemokine pathway with AMD3100 inhibits sunlight-induced skin cancer

One way sunlight causes skin cancer is by suppressing anti-tumor immunity. A major mechanism involves altering mast cell migration via the C-X-C motif chemokine receptor 4–C-X-C motif chemokine ligand 12 (CXCR4-CXCL12) chemokine pathway. We have discovered that pharmacologically blocking this pathwa...

Full description

Bibliographic Details
Main Authors:	Sarchio, Seri Narti Edayu, Scolyer, Richard A., Beaugie, Clare, McDonald, David, Marsh-Wakefield, Felix, Halliday, Gary M., Byrne, Scott N.
Format:	Article
Language:	English
Published:	Nature Publishing Group 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/34895/ http://psasir.upm.edu.my/id/eprint/34895/1/Pharmacologically%20antagonizing%20the%20CXCR4.pdf

Similar Items

AMD3100 protects from UV-induced skin cancer
by: Byrne, Scott N., et al.
Published: (2014)

Detection of infiltrating mast cells using a modified toluidine blue staining
by: Sarchio, Seri Narti Edayu
Published: (2017)

Aplikasi kesihatan digital pantau pesakit kronik
by: Sarchio, Seri Narti Edayu
Published: (2020)

MyBrain 2.0 perkasa generasi intelektual berkemahiran tinggi
by: Sarchio, Seri Narti Edayu
Published: (2023)

Sistem imun lawan covid-19
by: Sarchio, Seri Narti Edayu
Published: (2020)

Imuniti kelompok kawal putuskan rantaian jangkitan
by: Sarchio, Seri Narti Edayu
Published: (2020)

Kesan sampingan bukan indikator mutlak vaksin tak selamat
by: Sarchio, Seri Narti Edayu
Published: (2020)

Teknologi mRNA hasilkan vaksin berkesan, selamat
by: Sarchio, Seri Narti Edayu
Published: (2021)

Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2
by: Nesheva, Desislava
Published: (2022)

Small molecule-based fluorescent probes as tool compounds for chemokine receptors CXCR4 and ACKR3
by: Dekkers, Sebastian
Published: (2019)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M., et al.
Published: (2011)

Molecular mechanisms of enhanced expression of the chemokine interleukin 8 (CXCL8) in cystic fibrosis (CF) airway epithelial cells
by: Poghosyan, Anna
Published: (2014)

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
by: Manu, K., et al.
Published: (2011)

Evaluating the toxicity properties of Sesbania grandiflora ethanolic extract on zebrafish embryo
by: Ismail, Elysha Nur, et al.
Published: (2024)

The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization
by: Chakera, Aron, et al.
Published: (2008)

Polymeric Micelles encapsulating Sesbania grandiflora leaf extract on the antibacterial activity of Gram positive and Gram negative bacteria
by: Ismail, Elysha Nur, et al.
Published: (2024)

DAMA madahka finalis AMD
by: Utusan, Sarawak
Published: (2012)

Evaluation of phytochemical composition, antioxidant and anti- diabetic activities of Mitragyna speciosa Methanolic Extract (MSME)
by: Zailan, Nur Fatin Zalikha, et al.
Published: (2022)

Pencalonan AMD 2012 minggu ini
by: Utusan, Sarawak
Published: (2012)

AMD 2012 grand finale this Saturday
by: New Sarawak, Tribune
Published: (2012)

Tuberculosis after commencing antiretroviral therapy for HIV infection is associated with elevated CXCL9 and CXCL10 responses to Mycobacterium tuberculosis antigens.
by: Oliver, B., et al.
Published: (2012)

Gallic acid loaded graphene oxide based nanoformulation (GAGO) as potential anti-bacterial agent against staphylococcus aureus
by: Shamsi, Suhaili, et al.
Published: (2018)

Erratum: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-?B activation in breast and pancreatic tumor cells (Biochemical Pharmacology (2010) 80 (1553-1562))
by: Chua, A., et al.
Published: (2014)

Trees and sunlight
by: Tong, P.S.
Published: (2015)

Case Analysis On Advanced Micro Devices Inc.(AMD)
by: Ahmad, Normarina
Published: (2003)

AMD 2012 - Meri peransang ngagai artis Dayak
by: Utusan, Sarawak
Published: (2012)

Compartmentalised signalling and trafficking of CXCR4 and ACKR3
by: Karsai, Noemi
Published: (2025)

Inhibition of GSK-3 by Tideglusib suppresses activated macrophages and inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 cell line
by: Zailan, Nur Fatin Zalikha, et al.
Published: (2020)

Dynamics of ligand and nanobody binding at CXCR4/EGFR complexes
by: Comez, Dehan
Published: (2025)

Biokinetic test for the characterisation of AMD generation potential of sulfide mineral wastes
by: Hesketh, A.H., et al.
Published: (2010)

Projek Pistol to thrill fans at AMD 2012, 24 November 2012
by: New Sarawak, Tribune
Published: (2012)

Effects of CXCR4 siRNA/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver.
by: Abedini, Fatemeh, et al.
Published: (2011)

The copper conundrum: elucidating the modes of copper antagonism in the rumen
by: Clarkson, A.H.
Published: (2020)

Soil EC mapping system using Veris 3100 at young oil palm area / Nurul Amirah Ahmad Zaki
by: Ahmad Zaki, Nurul Amirah
Published: (2019)

Regulated chemokine gene expression in mouse mesothelioma and mesothelial cells: TNF-alpha upregulates both CC and CXC chemokine genes.
by: Fox, Simon, et al.
Published: (2012)

Toxicity assessment of gallic acid loaded graphene oxide (GAGO) nano-formulation in zebrafish (Danio rerio) embryos
by: Abdul Ghafor, Ahmad Ashraful Hadi, et al.
Published: (2020)

Toxicity assessment of ethanolic Moringa oleifera leaf extract (Mole) using zebrafish (Danio rerio) model
by: Sarchio, Seri Narti Edayu, et al.
Published: (2025)

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells
by: Poghosyan, Anna, et al.
Published: (2016)

Evaluation of CXCL10 as potential biomarker for early detection of severe dengue / Siti Noraihan Khamis
by: Khamis, Siti Noraihan
Published: (2019)

Articulating Islamist sectarian group antagonism memes on the Indonesian politics
by: Adi Bayu Mahadian,, et al.
Published: (2023)