Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion
Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of ketoprofen produces serious gastrointestinal adverse effects. One of the promising methods to overcome these adverse effec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Japan Oil Chemists' Society
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34848/ http://psasir.upm.edu.my/id/eprint/34848/1/Anti-inflammatory%20and%20analgesic%20effects%20of%20ketoprofen%20in%20palm%20oil%20esters%20nanoemulsion.pdf |
| _version_ | 1848847888641163264 |
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| author | M. H. F., Sakeena Yam, Mun Fei Mahdi, Elrashid Saleh Abdul Sattar, Munavvar Zubaid Mohd Noor, Azmin |
| author_facet | M. H. F., Sakeena Yam, Mun Fei Mahdi, Elrashid Saleh Abdul Sattar, Munavvar Zubaid Mohd Noor, Azmin |
| author_sort | M. H. F., Sakeena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of ketoprofen produces serious gastrointestinal adverse effects. One of the promising methods to overcome these adverse effects is to administer the drug through the skin. The aim of the present work is to evaluate the anti-inflammatory and analgesic effects from topically applied ketoprofen entrapped palm oil esters (POEs) based nanoemulsion and to compare with market ketoprofen product, Fastum® gel. The novelty of this study is, use of POEs for the oil phase of nanoemulsion. The anti-inflammatory and analgesic studies were performed on rats by carrageenan-induced rat hind paw edema test and carrageenan-induced hyperalgesia pain threshold test to compare the ketoprofen entrapped POEs based nanoemulsion formulation and market formulation. Results indicated that there are no significant different between ketoprofen entrapped POEs nanoemulsion and market formulation in carrageenan-induced rat hind paw edema study and carrageenan-induced hyperalgesia pain threshold study. However, it shows a significant different between POEs nanoemulsion formulation and control group in these studies at p<0.05. From these results it was concluded that the developed nanoemulsion have great potential for topical application of ketoprofen. |
| first_indexed | 2025-11-15T09:25:46Z |
| format | Article |
| id | upm-34848 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:25:46Z |
| publishDate | 2010 |
| publisher | Japan Oil Chemists' Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-348482016-10-10T05:33:05Z http://psasir.upm.edu.my/id/eprint/34848/ Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion M. H. F., Sakeena Yam, Mun Fei Mahdi, Elrashid Saleh Abdul Sattar, Munavvar Zubaid Mohd Noor, Azmin Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of ketoprofen produces serious gastrointestinal adverse effects. One of the promising methods to overcome these adverse effects is to administer the drug through the skin. The aim of the present work is to evaluate the anti-inflammatory and analgesic effects from topically applied ketoprofen entrapped palm oil esters (POEs) based nanoemulsion and to compare with market ketoprofen product, Fastum® gel. The novelty of this study is, use of POEs for the oil phase of nanoemulsion. The anti-inflammatory and analgesic studies were performed on rats by carrageenan-induced rat hind paw edema test and carrageenan-induced hyperalgesia pain threshold test to compare the ketoprofen entrapped POEs based nanoemulsion formulation and market formulation. Results indicated that there are no significant different between ketoprofen entrapped POEs nanoemulsion and market formulation in carrageenan-induced rat hind paw edema study and carrageenan-induced hyperalgesia pain threshold study. However, it shows a significant different between POEs nanoemulsion formulation and control group in these studies at p<0.05. From these results it was concluded that the developed nanoemulsion have great potential for topical application of ketoprofen. Japan Oil Chemists' Society 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34848/1/Anti-inflammatory%20and%20analgesic%20effects%20of%20ketoprofen%20in%20palm%20oil%20esters%20nanoemulsion.pdf M. H. F., Sakeena and Yam, Mun Fei and Mahdi, Elrashid Saleh and Abdul Sattar, Munavvar Zubaid and Mohd Noor, Azmin (2010) Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. Journal of Oleo Science, 59 (12). pp. 667-671. ISSN 1345-8957; ESSN: 1347-3352 https://www.jstage.jst.go.jp/article/jos/59/12/59_12_667/_article 10.5650/jos.59.667 |
| spellingShingle | M. H. F., Sakeena Yam, Mun Fei Mahdi, Elrashid Saleh Abdul Sattar, Munavvar Zubaid Mohd Noor, Azmin Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title_full | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title_fullStr | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title_full_unstemmed | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title_short | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| title_sort | anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion |
| url | http://psasir.upm.edu.my/id/eprint/34848/ http://psasir.upm.edu.my/id/eprint/34848/ http://psasir.upm.edu.my/id/eprint/34848/ http://psasir.upm.edu.my/id/eprint/34848/1/Anti-inflammatory%20and%20analgesic%20effects%20of%20ketoprofen%20in%20palm%20oil%20esters%20nanoemulsion.pdf |