Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials
Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammator...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34811/ http://psasir.upm.edu.my/id/eprint/34811/1/34811.pdf |
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| author | Rahman, Heshu Sulaiman Abdullah, Rasedee Yeap, Swee Keong Othman, Hemn Hassan Chartrand, Max Stanley Namvar, Farideh Abdul, Ahmad Bustamam How, Chee Wun |
| author_facet | Rahman, Heshu Sulaiman Abdullah, Rasedee Yeap, Swee Keong Othman, Hemn Hassan Chartrand, Max Stanley Namvar, Farideh Abdul, Ahmad Bustamam How, Chee Wun |
| author_sort | Rahman, Heshu Sulaiman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER. |
| first_indexed | 2025-11-15T09:25:36Z |
| format | Article |
| id | upm-34811 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:25:36Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-348112016-09-19T09:52:10Z http://psasir.upm.edu.my/id/eprint/34811/ Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials Rahman, Heshu Sulaiman Abdullah, Rasedee Yeap, Swee Keong Othman, Hemn Hassan Chartrand, Max Stanley Namvar, Farideh Abdul, Ahmad Bustamam How, Chee Wun Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34811/1/34811.pdf Rahman, Heshu Sulaiman and Abdullah, Rasedee and Yeap, Swee Keong and Othman, Hemn Hassan and Chartrand, Max Stanley and Namvar, Farideh and Abdul, Ahmad Bustamam and How, Chee Wun (2014) Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. BioMed Research International, 2014. art. no. 920742. pp. 1-20. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/920742/abs/ 10.1155/2014/920742 |
| spellingShingle | Rahman, Heshu Sulaiman Abdullah, Rasedee Yeap, Swee Keong Othman, Hemn Hassan Chartrand, Max Stanley Namvar, Farideh Abdul, Ahmad Bustamam How, Chee Wun Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title | Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title_full | Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title_fullStr | Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title_full_unstemmed | Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title_short | Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| title_sort | biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials |
| url | http://psasir.upm.edu.my/id/eprint/34811/ http://psasir.upm.edu.my/id/eprint/34811/ http://psasir.upm.edu.my/id/eprint/34811/ http://psasir.upm.edu.my/id/eprint/34811/1/34811.pdf |