NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

QR Code

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Andrographolide (AGP) is the main bioactive constituent isolated from the traditional medicinal, Andrographis paniculata which contributes towards its various biological activities, including anticancer property. In this study, a series of new AGP derivatives were semi-synthesised and screened again...

Full description

Bibliographic Details
Main Authors:	Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sumon, Shariful Hasan, Mohamad Sidik, Shiran, Phillips, Roger, Lajis, Nordin, Stanslas, Johnson
Format:	Article
Published:	Elsevier 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/34632/

Similar Items

Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets
by: Stanslas, Johnson, et al.
Published: (2010)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
by: Wong, Charng Choon, et al.
Published: (2014)

Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis
by: Jada, Srinivasa Rao, et al.
Published: (2008)

Semisynthesis and in vitro anticancer activities of andrographolide analogues
by: Jada, Srinivasa Rao, et al.
Published: (2007)

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
by: Wong, Hui Chyn, et al.
Published: (2014)

SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
by: Wong, Charng Choon, et al.
Published: (2016)

In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein
by: Shun, Ying Quah, et al.
Published: (2020)

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

Organic synthesis of 1,2-O-Isopropylidene-3-acyl glycerol by Amberlite XAD-7 adsorbed lipase of Pseudomonas sp. AK
by: Lo, Ya Sien, et al.
Published: (2004)

Elucidation of anticancer activity mechanism of 3,19-(2-Bromobenzylidene) andrographolide (SRJ09) in breast and colon cancer cells
by: Wong, Charng Choon
Published: (2016)

Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
by: Soo, Hon Liong, et al.
Published: (2019)

SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
by: Lim, Jonathan Chee Woei, et al.
Published: (2015)

Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
by: Shun, Ying Quah, et al.
Published: (2021)

Andrographolide downregulates pro-inflammatory cytokines and free radical productions to prevent dopaminergic neuro-degeneration induced by lipopolysaccharide
by: Sani, Dahiru, et al.
Published: (2014)

Solving linear system of partial differential equations by homotopy-pertubation method
by: Chowdhury, Md. Sazzad Hossien, et al.
Published: (2009)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
by: Hocker, Harrison J., et al.
Published: (2013)

In silico prediction of anticancer activity of Nitrosoureas
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2011)

NCI evalution: assessment of higher order thinking skills via short free text answer
by: Lajis, Adidah, et al.
Published: (2020)

An accurate solution to the nonlinear Lotka-Volterra equations by modified Homotopy Pertubation method
by: Chowdhury, Md. Sazzad Hossien
Published: (2013)

Anticancer activity of 3-O-acylated betulinic acid derivative obtained by enzymatic synthesis
by: Ahmad @ Amat, Faujan, et al.
Published: (2010)

Abrogation of oncogenic k-ras function by andrographolide derivatives via in silico, in vitro, and in vivo approaches
by: Quah, Shun Ying
Published: (2021)

Lipase-catalyzed acylation of quercetin with cinnamic acid
by: Saik, Amy Yi Hsan, et al.
Published: (2016)

Multi-branched benzylidene ketone based photoinitiators for multiphoton fabrication
by: Zhang, Fan, et al.
Published: (2017)

Synthesis and characterisation of smectic and nematic phases in 4-(Dimethylamino) benzylidene-4’-alkanoyloxyanilines
by: Gan, Yen Shing
Published: (2011)

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins
by: Jenner, Matthew, et al.
Published: (2016)

New semisynthetic andrographolide and 14-Deoxy-11, 12-didehydroandrographolide derivatives with anticancer, anti-histamine and nitric oxide inhibitory activities
by: Jeyaraj Asirvatham, Ethel Jeyaseela
Published: (2016)

Synthesis and characterization of acylated low molecular weight chitosan and acylated low molecular weight phthaloyl chitosan
by: Rahadian Permadi,, et al.
Published: (2020)

A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata nees
by: Valdiani, Alireza, et al.
Published: (2014)

Bioavailability Studies Of Andrographolide In Rats
by: Chia, Lee Huang
Published: (2016)

Synthesis, Characterization And Photoluminescence Properties Of Photocrosslinkable Benzylidene-Containing Polyesters And Their Potential Application As Chemosensor
by: Lim, Wan Leng
Published: (2017)

Biophysical and in silico characterization of the interaction of anticancer drugs with human serum albumin / Salanee Kandandapani
by: Salanee , Kandandapani
Published: (2022)

Synthesis and characterization of mesogenic schiff base ether, p-n-(Dimethylamino) benzylidene-p-alkyloxyanilines
by: Khor, Ke Xin
Published: (2011)

Utilizing Hirshfeld surface calculations, non-covalent interaction (NCI) plots and the calculation of interaction energies in the analysis of molecular packing
by: Tan, Sang Loon *, et al.
Published: (2019)

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review
by: Bagalkotkar, Gururaj, et al.
Published: (2006)

Acyl radical cascade reactions: the synthesis of azasteroids
by: Double, Philip John
Published: (1998)

Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
by: Manikam, Shiamala Devi, et al.
Published: (2009)

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb
by: Wahyuni, Fatma Sri, et al.
Published: (2017)

Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
by: Rao, Jada Srinivasa
Published: (2004)

Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine
by: Nor, Siti Mariam Mohd, et al.
Published: (2017)

Enzymatic enantioselective acylation of sterically aromatic secondary alcohol
by: Chua, Lee Suan, et al.
Published: (2005)