Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients

Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients

Palm phy­tonu­tri­ents found in crude palm oil con­sist of carotenes and tocols as well as other minor com­po­nents includ­ing sterols, squa­lene, ubiquinones, coen­zyme Q10 and phos­pho­lipids. Palm phy­tonu­tri­ents con­tains all the nat­u­rally occur­ring phy­tonu­tri­ents present in crude palm o...

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Main Authors: Loo, Chew Hung, Ismail, Rosnah, Basri, Mahiran, Lau, Harrison Lik Nang, Tejo, Bimo Ario, Abu Hassan, Hazimah, Choo, Yuen May, M. S. Subramaniam, Kanthimathi
Format: Article
Language:English
Published: Malaysian Palm Oil Board 2014
Online Access:http://psasir.upm.edu.my/id/eprint/34626/
http://psasir.upm.edu.my/id/eprint/34626/1/Nanostructured%20lipid%20carriers%20%28NLC%29%20for%20efficient%20delivery%20of%20palm%20phytonutrients.pdf
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author Loo, Chew Hung
Ismail, Rosnah
Basri, Mahiran
Lau, Harrison Lik Nang
Tejo, Bimo Ario
Abu Hassan, Hazimah
Choo, Yuen May
M. S. Subramaniam, Kanthimathi
author_facet Loo, Chew Hung
Ismail, Rosnah
Basri, Mahiran
Lau, Harrison Lik Nang
Tejo, Bimo Ario
Abu Hassan, Hazimah
Choo, Yuen May
M. S. Subramaniam, Kanthimathi
author_sort Loo, Chew Hung
building UPM Institutional Repository
collection Online Access
description Palm phy­tonu­tri­ents found in crude palm oil con­sist of carotenes and tocols as well as other minor com­po­nents includ­ing sterols, squa­lene, ubiquinones, coen­zyme Q10 and phos­pho­lipids. Palm phy­tonu­tri­ents con­tains all the nat­u­rally occur­ring phy­tonu­tri­ents present in crude palm oil, whereas com­mer­cially avail­able indi­vid­ual phy­tonu­tri­ents, such as Gold-tri E and Tocomin 50% mainly con­sist of palm tocotrienols. The encap­su­la­tion of palm phy­tonu­tri­ents by nanos­truc­tured lipid car­ri­ers (NLC) was inves­ti­gated using Trans­mis­sion Elec­tron Microscopy. NLC was proven to effec­tively encap­su­late palm phy­tonu­tri­ents in oil droplets. Based on the par­ti­cle size analy­sis and rhe­o­log­i­cal study, NLC was found to be the most phys­i­cally sta­ble deliv­ery sys­tem when com­pared to the macro-emulsion and the nano-emulsion car­ri­ers. The long-term chem­i­cal sta­bil­ity of the palm phy­tonu­tri­ent using β-carotene as the pro­to­type active in NLC was also deter­mined. The degra­da­tion of β-carotene in NLC was lower when com­pared to the macro-emulsion and the nano-emulsion car­ri­ers. The effi­cacy of NLC as a deliv­ery sys­tem and the effect of the addi­tion of lecithin and propy­lene gly­col to the NLC for­mu­la­tion were also stud­ied. The para­me­ters inves­ti­gated were skin hydra­tion and trans-epidermal water loss (TEWL). NLC with the pres­ence of 1% lecithin and 2% propy­lene gly­col were found to enhance skin hydra­tion and pre­vent water loss.
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institution Universiti Putra Malaysia
institution_category Local University
language English
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publishDate 2014
publisher Malaysian Palm Oil Board
recordtype eprints
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spelling upm-346262016-09-19T03:50:50Z http://psasir.upm.edu.my/id/eprint/34626/ Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients Loo, Chew Hung Ismail, Rosnah Basri, Mahiran Lau, Harrison Lik Nang Tejo, Bimo Ario Abu Hassan, Hazimah Choo, Yuen May M. S. Subramaniam, Kanthimathi Palm phy­tonu­tri­ents found in crude palm oil con­sist of carotenes and tocols as well as other minor com­po­nents includ­ing sterols, squa­lene, ubiquinones, coen­zyme Q10 and phos­pho­lipids. Palm phy­tonu­tri­ents con­tains all the nat­u­rally occur­ring phy­tonu­tri­ents present in crude palm oil, whereas com­mer­cially avail­able indi­vid­ual phy­tonu­tri­ents, such as Gold-tri E and Tocomin 50% mainly con­sist of palm tocotrienols. The encap­su­la­tion of palm phy­tonu­tri­ents by nanos­truc­tured lipid car­ri­ers (NLC) was inves­ti­gated using Trans­mis­sion Elec­tron Microscopy. NLC was proven to effec­tively encap­su­late palm phy­tonu­tri­ents in oil droplets. Based on the par­ti­cle size analy­sis and rhe­o­log­i­cal study, NLC was found to be the most phys­i­cally sta­ble deliv­ery sys­tem when com­pared to the macro-emulsion and the nano-emulsion car­ri­ers. The long-term chem­i­cal sta­bil­ity of the palm phy­tonu­tri­ent using β-carotene as the pro­to­type active in NLC was also deter­mined. The degra­da­tion of β-carotene in NLC was lower when com­pared to the macro-emulsion and the nano-emulsion car­ri­ers. The effi­cacy of NLC as a deliv­ery sys­tem and the effect of the addi­tion of lecithin and propy­lene gly­col to the NLC for­mu­la­tion were also stud­ied. The para­me­ters inves­ti­gated were skin hydra­tion and trans-epidermal water loss (TEWL). NLC with the pres­ence of 1% lecithin and 2% propy­lene gly­col were found to enhance skin hydra­tion and pre­vent water loss. Malaysian Palm Oil Board 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34626/1/Nanostructured%20lipid%20carriers%20%28NLC%29%20for%20efficient%20delivery%20of%20palm%20phytonutrients.pdf Loo, Chew Hung and Ismail, Rosnah and Basri, Mahiran and Lau, Harrison Lik Nang and Tejo, Bimo Ario and Abu Hassan, Hazimah and Choo, Yuen May and M. S. Subramaniam, Kanthimathi (2014) Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients. Journal of Oil Palm Research, 26 (3). pp. 232-239. ISSN 1511-2780 http://jopr.mpob.gov.my/nanostructured-lipid-carriers-nlc-for-efficient-delivery-of-palm-phytonutrients/
spellingShingle Loo, Chew Hung
Ismail, Rosnah
Basri, Mahiran
Lau, Harrison Lik Nang
Tejo, Bimo Ario
Abu Hassan, Hazimah
Choo, Yuen May
M. S. Subramaniam, Kanthimathi
Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title_full Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title_fullStr Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title_full_unstemmed Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title_short Nanostructured lipid carriers (NLC) for efficient delivery of palm phytonutrients
title_sort nanostructured lipid carriers (nlc) for efficient delivery of palm phytonutrients
url http://psasir.upm.edu.my/id/eprint/34626/
http://psasir.upm.edu.my/id/eprint/34626/
http://psasir.upm.edu.my/id/eprint/34626/1/Nanostructured%20lipid%20carriers%20%28NLC%29%20for%20efficient%20delivery%20of%20palm%20phytonutrients.pdf

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