Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity
Salicylaldehyde-4-methylthiosemicarbazone (H2MTSali) has been prepared via the condensation reaction of 4-methyl-3-thiosemicarbazide and salicylaldehyde. Four new mixed-ligand copper(II) and nickel(II) complexes with a general formula [M(MTSali)L] (M = Cu2+ or Ni2+; L = co-ligand) were synthesized,...
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| Format: | Article |
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Springer
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34536/ |
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| author | Mazlan, Nurul Ain S. A. Ravoof, Thahira Begum Tiekink, Edward R. T. Mohamed Tahir, Mohamed Ibrahim Veerakumarasivam, Abhi Crouse, Karen Anne |
| author_facet | Mazlan, Nurul Ain S. A. Ravoof, Thahira Begum Tiekink, Edward R. T. Mohamed Tahir, Mohamed Ibrahim Veerakumarasivam, Abhi Crouse, Karen Anne |
| author_sort | Mazlan, Nurul Ain |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Salicylaldehyde-4-methylthiosemicarbazone (H2MTSali) has been prepared via the condensation reaction of 4-methyl-3-thiosemicarbazide and salicylaldehyde. Four new mixed-ligand copper(II) and nickel(II) complexes with a general formula [M(MTSali)L] (M = Cu2+ or Ni2+; L = co-ligand) were synthesized, where L is either imidazole (im) or benzimidazole (bzim). The Schiff base and its mixed-ligand complexes were characterized by IR and UV/Vis spectroscopy, and the complexes by molar conductivity and magnetic susceptibility measurements. The spectroscopic data indicated that the Schiff base behaves as a tridentate ONS donor ligand coordinating via the phenoxide-oxygen, azomethine-nitrogen, and thiolate-sulphur atoms. Magnetic data indicate a square planar environment for the nickel(II) complexes while molar conductance values indicate that the metal complexes are essentially non-electrolytes in DMSO solution. X-ray crystallography shows Cu(MTSali)bzim (1) and Ni(MTSali)bzim (3) to be isostructural, with the metal(II) ions being coordinated by a N2OS donor set that defines an approximate square planar geometry; in both cases, the benzimidazole is splayed with respect to the coordination plane. The copper(II) complexes were active against MDA-MB-231 and MCF-7 breast cancer cell lines, more so than H2MTSali, whereas the nickel(II) complexes were inactive. |
| first_indexed | 2025-11-15T09:24:21Z |
| format | Article |
| id | upm-34536 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:24:21Z |
| publishDate | 2014 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-345362015-12-16T00:40:27Z http://psasir.upm.edu.my/id/eprint/34536/ Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity Mazlan, Nurul Ain S. A. Ravoof, Thahira Begum Tiekink, Edward R. T. Mohamed Tahir, Mohamed Ibrahim Veerakumarasivam, Abhi Crouse, Karen Anne Salicylaldehyde-4-methylthiosemicarbazone (H2MTSali) has been prepared via the condensation reaction of 4-methyl-3-thiosemicarbazide and salicylaldehyde. Four new mixed-ligand copper(II) and nickel(II) complexes with a general formula [M(MTSali)L] (M = Cu2+ or Ni2+; L = co-ligand) were synthesized, where L is either imidazole (im) or benzimidazole (bzim). The Schiff base and its mixed-ligand complexes were characterized by IR and UV/Vis spectroscopy, and the complexes by molar conductivity and magnetic susceptibility measurements. The spectroscopic data indicated that the Schiff base behaves as a tridentate ONS donor ligand coordinating via the phenoxide-oxygen, azomethine-nitrogen, and thiolate-sulphur atoms. Magnetic data indicate a square planar environment for the nickel(II) complexes while molar conductance values indicate that the metal complexes are essentially non-electrolytes in DMSO solution. X-ray crystallography shows Cu(MTSali)bzim (1) and Ni(MTSali)bzim (3) to be isostructural, with the metal(II) ions being coordinated by a N2OS donor set that defines an approximate square planar geometry; in both cases, the benzimidazole is splayed with respect to the coordination plane. The copper(II) complexes were active against MDA-MB-231 and MCF-7 breast cancer cell lines, more so than H2MTSali, whereas the nickel(II) complexes were inactive. Springer 2014-09 Article PeerReviewed Mazlan, Nurul Ain and S. A. Ravoof, Thahira Begum and Tiekink, Edward R. T. and Mohamed Tahir, Mohamed Ibrahim and Veerakumarasivam, Abhi and Crouse, Karen Anne (2014) Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity. Transition Metal Chemistry, 39 (6). pp. 633-639. ISSN 0340-4285; ESSN: 1572-901X http://link.springer.com/article/10.1007%2Fs11243-014-9842-9 10.1007/s11243-014-9842-9 |
| spellingShingle | Mazlan, Nurul Ain S. A. Ravoof, Thahira Begum Tiekink, Edward R. T. Mohamed Tahir, Mohamed Ibrahim Veerakumarasivam, Abhi Crouse, Karen Anne Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title | Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title_full | Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title_fullStr | Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title_full_unstemmed | Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title_short | Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| title_sort | mixed-ligand metal complexes containing an ons schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity |
| url | http://psasir.upm.edu.my/id/eprint/34536/ http://psasir.upm.edu.my/id/eprint/34536/ http://psasir.upm.edu.my/id/eprint/34536/ |