Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats
This study was aimed to evaluate the microscopic changes that occur within the ovary and to assess the level of inflammatory mediators in blood plasma in rats that are superovulated. Eighteen female 12 weeks old Sprague Dawley rats were used in this study whereby histological sections of ovaries wer...
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| Format: | Article |
| Language: | English |
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Asian Online Journals
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34518/ http://psasir.upm.edu.my/id/eprint/34518/1/Microscopic%20changes%20of%20ovaries%20in%20relation%20to%20inflammatory%20mediators%20of%20blood%20plasma%20in%20superovulated%20rats.pdf |
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| author | Gopalsamy, Banulata Ganabadi, Shanthi Tengku Ibrahim, Tengku Azmi Yaakub, Halimatun |
| author_facet | Gopalsamy, Banulata Ganabadi, Shanthi Tengku Ibrahim, Tengku Azmi Yaakub, Halimatun |
| author_sort | Gopalsamy, Banulata |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was aimed to evaluate the microscopic changes that occur within the ovary and to assess the level of inflammatory mediators in blood plasma in rats that are superovulated. Eighteen female 12 weeks old Sprague Dawley rats were used in this study whereby histological sections of ovaries were examined to study the morphology of the ovary and blood analysis was carried out to analyse the inflammatory mediators in the blood plasma. The number of large follicles and healthy follicles were significantly increased (P<0.05) in superovulated rats but the diameter of the follicles were indifferent (P>0.05) when compared to control rats. The levels of Interleukin 8 (IL-8) was up regulated (P<0.05) at 8 hours after human Chorionic Gonadotropin (hCG) treatment but the Prostaglandin E2 (PGE2) and Nerve Growth Factor (NGF) showed insignificant differences (P>0.05) from control rats. It can be concluded from this study that IL-8 indicates increased level of inflammation in superovulated rats. The finding of this study in the increased level of IL-8 in superovulated rats is useful in further studies addressing problems in the superovulation treatment. |
| first_indexed | 2025-11-15T09:24:17Z |
| format | Article |
| id | upm-34518 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:24:17Z |
| publishDate | 2014 |
| publisher | Asian Online Journals |
| recordtype | eprints |
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| spelling | upm-345182017-10-23T09:12:07Z http://psasir.upm.edu.my/id/eprint/34518/ Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats Gopalsamy, Banulata Ganabadi, Shanthi Tengku Ibrahim, Tengku Azmi Yaakub, Halimatun This study was aimed to evaluate the microscopic changes that occur within the ovary and to assess the level of inflammatory mediators in blood plasma in rats that are superovulated. Eighteen female 12 weeks old Sprague Dawley rats were used in this study whereby histological sections of ovaries were examined to study the morphology of the ovary and blood analysis was carried out to analyse the inflammatory mediators in the blood plasma. The number of large follicles and healthy follicles were significantly increased (P<0.05) in superovulated rats but the diameter of the follicles were indifferent (P>0.05) when compared to control rats. The levels of Interleukin 8 (IL-8) was up regulated (P<0.05) at 8 hours after human Chorionic Gonadotropin (hCG) treatment but the Prostaglandin E2 (PGE2) and Nerve Growth Factor (NGF) showed insignificant differences (P>0.05) from control rats. It can be concluded from this study that IL-8 indicates increased level of inflammation in superovulated rats. The finding of this study in the increased level of IL-8 in superovulated rats is useful in further studies addressing problems in the superovulation treatment. Asian Online Journals 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34518/1/Microscopic%20changes%20of%20ovaries%20in%20relation%20to%20inflammatory%20mediators%20of%20blood%20plasma%20in%20superovulated%20rats.pdf Gopalsamy, Banulata and Ganabadi, Shanthi and Tengku Ibrahim, Tengku Azmi and Yaakub, Halimatun (2014) Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats. Asian Journal of Applied Sciences, 2 (4). pp. 427-436. ISSN 2321-0893 https://www.ajouronline.com/index.php/AJAS/article/view/1505 |
| spellingShingle | Gopalsamy, Banulata Ganabadi, Shanthi Tengku Ibrahim, Tengku Azmi Yaakub, Halimatun Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title | Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title_full | Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title_fullStr | Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title_full_unstemmed | Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title_short | Microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| title_sort | microscopic changes of ovaries in relation to inflammatory mediators of blood plasma in superovulated rats |
| url | http://psasir.upm.edu.my/id/eprint/34518/ http://psasir.upm.edu.my/id/eprint/34518/ http://psasir.upm.edu.my/id/eprint/34518/1/Microscopic%20changes%20of%20ovaries%20in%20relation%20to%20inflammatory%20mediators%20of%20blood%20plasma%20in%20superovulated%20rats.pdf |